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PMID: 53265 Published · ppublish English Journal Article

Induction of cytotoxic T lymphocytes against I-region-coded determinants: in vitro evidence for a third histocompatibility locus in the mouse.

The Journal of experimental medicine ·Vol. 142 ·No. 6 ·1975-12-01 ·Pages 1477-87

Wagner H, Götze D, Ptschelinzew L, Röllinghoff M

Abstract

Determinants controlled by the I region of the murine H-2 complex provoked the generation of cytotoxic T lymphocytes (CTL) in both a secondary and primary mixed lymphocyte culture. The stimulating determinants appeared to be controlled by loci within the I-A subregion. The target antigens of the CTL generated were present on both lipopolysaccharide- and concanavalin-induced blast lymphocytes, but were barely detectable on phytohemagglutinin-induced blast cells. The stimulating capacity for CTL induction of a complete H-2 complex incompatibility by far exceeded the sum of H-2D/K-region and I-region incompatibility, respectively.

MeSH Terms
Animals Antigen-Antibody Reactions Concanavalin A Epitopes Histocompatibility Antigens Hybridization, Genetic Lectins Lipopolysaccharides Lymphocyte Activation Lymphocyte Culture Test, Mixed Mice Mice, Inbred Strains/immunology Species Specificity T-Lymphocytes/immunology
Chemicals
Epitopes Histocompatibility Antigens Lectins Lipopolysaccharides Concanavalin A
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wagner H
Götze D
Ptschelinzew L
Röllinghoff M
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29 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.142.6.1477
Published
1975-12-01
Pages
1477-87
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190067
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.142.6.1477 PMC Full Text View journal details
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