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PMID: 8282808 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission.

The Journal of clinical investigation ·Vol. 93 ·No. 1 ·1994-01-00 ·Pages 380-90

Lamers SL, Sleasman JW, She JX, Barrie KA, Pomeroy SM, Barrett DJ, Goodenow MM

Abstract

The extent of nucleotide variation within the HIV-1 env hypervariable domains serves as a marker of virus genotypes within infected individuals and as a means to track transmission of the virus between individuals. We analyzed env V1 and V2 sequences in longitudinal samples from two HIV-1-infected mothers, each with three children infected by maternal transmission of the virus. Sequences in samples that were obtained from two infants at 2 d and 4 wk after birth displayed more variation in V1 and V2 than maternal samples obtained at the same times. Multiple HIV-1 genotypes were identified in each mother. In each family, multiple maternal HIV-1 genotypes were transmitted to the infants. Specific amino acid residues in the hypervariable domains were conserved within sequences from each family producing a family-specific amino acid signature pattern in V1 and V2. Viruses that were highly related to maternal viruses in signature pattern persisted for as long as 4 yr in the older children. Results support a model of transmission involving multiple HIV-1 genotypes with development of genetic variation from differential outgrowth and accumulation of genetic changes within each individual.

Related Genes
env
MeSH Terms
Acquired Immunodeficiency Syndrome/microbiology,transmission Amino Acid Sequence Child, Preschool Female Gene Products, env/genetics Genes, env Genetic Variation Genotype HIV-1/genetics,isolation & purification Humans Infant Infant, Newborn Longitudinal Studies Molecular Sequence Data Phylogeny Pregnancy Pregnancy Complications, Infectious/microbiology Sequence Homology, Amino Acid
Chemicals
Gene Products, env
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Lamers S L
Department of Pathology, University of Florida College of Medicine, Gainesville 32610.
Sleasman J W
She J X
Barrie K A
Pomeroy S M
Barrett D J
Goodenow M M
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI116970
Published
1994-01-00
Pages
380-90
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC293789
Subset
IM
Grants
PHS HHS · R01 28210 · United States
External Links
PubMed source DOI: 10.1172/JCI116970 PMC Full Text View journal details
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