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PMID: 8183904 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Codon reiteration and the evolution of proteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 10 ·1994-05-10 ·Pages 4298-302

Green H, Wang N

Abstract

Sequence data banks have been searched for proteins possessing uninterrupted reiterations of any amino acid. Hydrophilic amino acids, and particularly glutamine, account for a large proportion of the longer reiterants. In the genes for these proteins, the most common reiterants are those that contain poly(CAG), even out-of-frame or, to a lesser degree, those that contain repeated doublets of CA, AG, or GC. The preferential generation of such reiterants requires that DNA strand-specific signals predispose to reiteration and thus to the extension of coding regions.

Related Genes
mam
MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Codon/genetics Databases, Factual Drosophila/genetics Humans Molecular Sequence Data Proteins/chemistry,genetics Saccharomyces cerevisiae/genetics
Chemicals
Codon Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Green H
Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
Wang N
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.10.4298
Published
1994-05-10
Pages
4298-302
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC43772
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.91.10.4298 PMC Full Text View journal details
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