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PMID: 1861978 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID).

Nucleic acids research ·Vol. 19 ·No. 14 ·1991-07-25 ·Pages 3861-5

Tamura T, Sumita K, Fujino I, Aoyama A, Horikoshi M, Hoffmann A, Roeder RG, Muramatsu M, Mikoshiba K

Abstract

A complementary DNA (cDNA) encoding a mouse TFIID (mIID) was isolated from mouse brain cDNA libraries. The 316 amino acid sequence deduced from cDNA sequences revealed the presence of an amino-terminal region enriched in serine, threonine, and proline (STP-cluster), an uninterrupted stretch of 13 glutamine residues (Q-run), a second STP-cluster, and a conserved carboxy-terminal region. Amino acid sequences of the first STP-cluster and the conserved carboxy-terminal region were identical to those of the human TFIID (hIID). However, the Q-run was considerably shorter than that in hIID and sequences in the second STP-cluster diverged from those of the hIID. The murine TFIID transcript is expressed as a 2 kilobase poly(A)+ RNA in the mouse brain. Southern blot analysis identified a single gene copy per haploid mouse genome.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Blotting, Southern DNA Humans Mice Molecular Sequence Data Sequence Homology, Nucleic Acid Transcription Factor TFIID Transcription Factors/genetics
Chemicals
Transcription Factor TFIID Transcription Factors DNA
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Tamura T
Division of Behavior and Neurobiology, National Institute for Basic Biology, Okazaki, Japan.
Sumita K
Fujino I
Aoyama A
Horikoshi M
Hoffmann A
Roeder R G
Muramatsu M
Mikoshiba K
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/19.14.3861
Published
1991-07-25
Pages
3861-5
Language
English
Region
England
NLM ID
0411011
PMCID
PMC328475
Subset
IM
Databases
GENBANK
D01034, X56865, X57509, X57510, X58037, X58038, X58104, X58105, X58106, X58496
External Links
PubMed source DOI: 10.1093/nar/19.14.3861 PMC Full Text View journal details
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