Home LiteratureArticle Details
PMID: 8139576 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.

Molecular and cellular biology ·Vol. 14 ·No. 4 ·1994-04-00 ·Pages 2786-97

Ellinger-Ziegelbauer H, Hihi AK, Laudet V, Keller H, Wahli W, Dreyer C

Abstract

Orphan receptors of the FTZ-F1-related group of nuclear receptors (xFF1r) were identified in Xenopus laevis by isolation of cDNAs from a neurula stage library. Two cDNAs were found, which encode full length, highly related receptor proteins, xFF1rA and B, whose closet relative known so far is the murine LRH-1 orphan receptor. xFF1rA protein expressed by a recombinant vaccinia virus system specifically binds to FTZ-F1 response elements (FRE; PyCAAGGPyCPu). In cotransfection studies, xFF1rA constitutively activates transcription, in a manner dependent on the number of FREs. The amounts of at least four mRNAs encoding full-length receptors greatly increase between gastrula and early tailbud stages and decrease at later stages. At early tailbud stages, xFTZ-F1-related antigens are found in all nuclei of the embryo.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Carrier Proteins/biosynthesis,isolation & purification Cattle Cloning, Molecular DNA, Complementary/metabolism DNA-Binding Proteins/biosynthesis Drosophila Proteins Drosophila melanogaster/metabolism Embryo, Nonmammalian/physiology Fushi Tarazu Transcription Factors Gene Expression Globins/genetics HeLa Cells Homeodomain Proteins Humans Insect Proteins Membrane Proteins/biosynthesis,isolation & purification Mice Molecular Sequence Data Oligodeoxyribonucleotides Phylogeny Promoter Regions, Genetic RNA, Messenger/isolation & purification,metabolism Receptors, Cytoplasmic and Nuclear Receptors, Steroid/biosynthesis Restriction Mapping Steroidogenic Factor 1 Transcription Factors/biosynthesis Transcription, Genetic Transfection Xenopus laevis/embryology
Chemicals
Carrier Proteins DNA, Complementary DNA-Binding Proteins Drosophila Proteins Fushi Tarazu Transcription Factors Homeodomain Proteins Insect Proteins Membrane Proteins Oligodeoxyribonucleotides RNA, Messenger Receptors, Cytoplasmic and Nuclear Receptors, Steroid Steroidogenic Factor 1 Transcription Factors ftz protein, Drosophila nuclear hormone receptor FTZ-F1, Drosophila Globins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ellinger-Ziegelbauer H
Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Federal Republic of Germany.
Hihi A K
Laudet V
Keller H
Wahli W
Dreyer C
References (57)
57 references, click to expand
  1. Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
    J Biol Chem. 1993 Apr 5;268(10):7494-502 PMID: 8463279
  2. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.
    Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4 PMID: 8384714
  3. Potential role for a FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis.
    Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3004-8 PMID: 8096644
  4. Functional conservation of vertebrate seven-up related genes in neurogenesis and eye development.
    EMBO J. 1993 Apr;12(4):1403-14 PMID: 8467797
  5. The orphan receptor Rev-ErbA alpha activates transcription via a novel response element.
    Mol Cell Biol. 1993 May;13(5):3113-21 PMID: 8474464
  6. Activation and repression of Drosophila alcohol dehydrogenase distal transcription by two steroid hormone receptor superfamily members binding to a common response element.
    Nucleic Acids Res. 1993 Apr 11;21(7):1619-27 PMID: 8479913
  7. cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3',5'-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells.
    Mol Endocrinol. 1993 Mar;7(3):341-54 PMID: 8387157
  8. Ancestry and diversity of the HMG box superfamily.
    Nucleic Acids Res. 1993 May 25;21(10):2493-501 PMID: 8506143
  9. The pattern of retinoic acid receptor gamma (RAR gamma) expression in normal development of Xenopus laevis and after manipulation of the main body axis.
    Mech Dev. 1993 Apr;41(1):33-46 PMID: 8389582
  10. Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR).
    Biol Cell. 1993;77(1):67-76 PMID: 8390886
  11. Mechanisms of transactivation by retinoic acid receptors.
    Bioessays. 1993 May;15(5):309-15 PMID: 8393666
  12. Steroid and related receptors.
    Curr Opin Cell Biol. 1993 Jun;5(3):499-504 PMID: 8352968
  13. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.
    Mol Cell Biol. 1993 Sep;13(9):5794-804 PMID: 8395013
  14. Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues.
    Mol Endocrinol. 1993 Jun;7(6):776-86 PMID: 8395654
  15. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.
    Mol Endocrinol. 1993 Jul;7(7):852-60 PMID: 8413309
  16. A common ancestor DNA motif for invertebrate and vertebrate hormone response elements.
    EMBO J. 1991 Feb;10(2):263-8 PMID: 1846802
  17. Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe expression.
    Genes Dev. 1991 May;5(5):855-67 PMID: 1851122
  18. FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu.
    Science. 1991 May 10;252(5007):848-51 PMID: 1709303
  19. Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.
    FASEB J. 1991 Jun;5(9):2243-9 PMID: 1860615
  20. RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.
    Cell. 1991 Dec 20;67(6):1251-66 PMID: 1662118
  21. Removal of fatty acids from serum albumin by charcoal treatment.
    J Biol Chem. 1967 Jan 25;242(2):173-81 PMID: 6016603
  22. A new technique for the assay of infectivity of human adenovirus 5 DNA.
    Virology. 1973 Apr;52(2):456-67 PMID: 4705382
  23. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
    Mol Cell Biol. 1982 Sep;2(9):1044-51 PMID: 6960240
  24. A comprehensive set of sequence analysis programs for the VAX.
    Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 PMID: 6546423
  25. One hundred base pairs of 5' flanking sequence of a vaccinia virus late gene are sufficient to temporally regulate late transcription.
    Proc Natl Acad Sci U S A. 1985 Apr;82(7):2096-100 PMID: 3856886
  26. The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors.
    EMBO J. 1986 May;5(5):891-7 PMID: 3755102
  27. Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA.
    Cell. 1986 Aug 1;46(3):389-99 PMID: 3755378
  28. Tissue-specific in vitro transcription from the mouse albumin promoter.
    Cell. 1986 Dec 5;47(5):767-76 PMID: 3779841
  29. Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction.
    Development. 1987 Mar;99(3):311-25 PMID: 2443340
  30. In vitro RNA synthesis with SP6 RNA polymerase.
    Methods Enzymol. 1987;155:397-415 PMID: 2828872
  31. Copper staining: a five-minute protein stain for sodium dodecyl sulfate-polyacrylamide gels.
    Anal Biochem. 1987 Nov 1;166(2):308-12 PMID: 2449094
  32. Phylogenies from molecular sequences: inference and reliability.
    Annu Rev Genet. 1988;22:521-65 PMID: 3071258
  33. Construction of plasmids that express E. coli beta-galactosidase in mammalian cells.
    Nucleic Acids Res. 1989 Mar 25;17(6):2365 PMID: 2495524
  34. COUP transcription factor is a member of the steroid receptor superfamily.
    Nature. 1989 Jul 13;340(6229):163-6 PMID: 2739739
  35. Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model.
    Mol Endocrinol. 1990 Sep;4(9):1293-301 PMID: 2172797
  36. A retinoic acid receptor expressed in the early development of Xenopus laevis.
    Genes Dev. 1991 Jan;5(1):94-104 PMID: 1846602
  37. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
    Cell. 1992 Jan 24;68(2):377-95 PMID: 1310259
  38. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors.
    Nature. 1992 Jan 30;355(6359):441-6 PMID: 1310350
  39. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.
    Nature. 1992 Jan 30;355(6359):446-9 PMID: 1310351
  40. Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily.
    Mol Cell Biol. 1992 Mar;12(3):1286-91 PMID: 1545809
  41. Evolution of the nuclear receptor gene superfamily.
    EMBO J. 1992 Mar;11(3):1003-13 PMID: 1312460
  42. RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.
    EMBO J. 1992 Apr;11(4):1409-18 PMID: 1314167
  43. H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.
    EMBO J. 1992 Apr;11(4):1419-35 PMID: 1314168
  44. Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors.
    Science. 1992 Apr 3;256(5053):107-10 PMID: 1314418
  45. Isolation of high affinity cellular targets of the embryonal LTR binding protein, an undifferentiated embryonal carcinoma cell-specific repressor of Moloney leukemia virus.
    Nucleic Acids Res. 1992 Apr 11;20(7):1477-82 PMID: 1579438
  46. Domains regulating transcriptional activity of the inducible orphan receptor NGFI-B.
    J Biol Chem. 1992 Aug 15;267(23):16491-6 PMID: 1644831
  47. New vectors for high level expression of recombinant proteins in bacteria.
    Anal Biochem. 1992 May 1;202(2):293-8 PMID: 1519755
  48. Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation.
    Cell. 1992 Oct 2;71(1):63-72 PMID: 1327536
  49. Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.
    Mol Endocrinol. 1992 Aug;6(8):1249-58 PMID: 1406703
  50. Orphan receptors: in search of a unifying hypothesis for activation.
    Mol Endocrinol. 1992 Sep;6(9):1359-61 PMID: 1331771
  51. A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein.
    Mol Cell Biol. 1992 Dec;12(12):5667-72 PMID: 1448096
  52. The Antennapedia-type homeobox genes have evolved from three precursors separated early in metazoan evolution.
    Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):143-7 PMID: 8093557
  53. Evolution of the ets gene family.
    Biochem Biophys Res Commun. 1993 Jan 15;190(1):8-14 PMID: 8422262
  54. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase.
    Mol Cell Biol. 1993 Feb;13(2):861-8 PMID: 8380897
  55. The powers and pitfalls of parsimony.
    Nature. 1993 Feb 18;361(6413):603-7 PMID: 8437621
  56. FTZ-F1 beta, a novel member of the Drosophila nuclear receptor family.
    Mech Dev. 1993 Jan;40(1-2):13-24 PMID: 8382937
  57. Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle.
    Nature. 1993 Apr 1;362(6419):471-5 PMID: 8385270
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.14.4.2786-2797.1994
Published
1994-04-00
Pages
2786-97
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC358644
Subset
IM
Databases
GENBANK
U05001, U05003
External Links
PubMed source DOI: 10.1128/mcb.14.4.2786-2797.1994 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2