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PMID: 8126181 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

VP4 genotyping of human rotavirus in the United States.

Journal of clinical microbiology ·Vol. 32 ·No. 1 ·1994-01-00 ·Pages 205-8

Santos N, Riepenhoff-Talty M, Clark HF, Offit P, Gouvea V

Abstract

The VP4 (P) and VP7 (G) types of 171 rotavirus isolates obtained from children with diarrhea in the United States were characterized by PCR typing assays. Strains P1G1 predominated (71%); this was followed by strains P1G3 (20%) and P2G2 and P1G4 (2% each). Mixed types were identified in five (3%) specimens. Two (1%) strains bearing the P3 genotype (P3G1 and P3G2) were found in children with severe dehydrating diarrhea, although the P3 genotype has been regarded as a possible marker for virus attenuation.

MeSH Terms
Antigens, Viral Capsid/genetics Capsid Proteins Child Diarrhea/genetics,microbiology Genes, Viral/genetics Genetic Markers Genotype Humans Polymerase Chain Reaction Rotavirus Infections/classification,epidemiology,genetics United States/epidemiology
Chemicals
Antigens, Viral Capsid Proteins Genetic Markers VP4 protein, Rotavirus VP7 protein, Rotavirus
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Santos N
Division of Molecular Biological Research and Evaluation, Food and Drug Administration, Washington, DC 20204.
Riepenhoff-Talty M
Clark H F
Offit P
Gouvea V
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32 references, click to expand
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.32.1.205-208.1994
Published
1994-01-00
Pages
205-8
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC262997
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.32.1.205-208.1994 PMC Full Text View journal details
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