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PMID: 8109938 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 12 ·1993-12-00 ·Pages 2699-705

Hansen LM, McMurry LM, Levy SB, Hirsh DC

Abstract

The tetracycline resistance determinant on plasmid pVM111 from an avian strain of Pasteurella multocida mediates tetracycline resistance by a regulated active efflux mechanism. DNA coding for the determinant did not hybridize at high stringency with DNA representing a group of common tetracycline resistance determinants. The DNA sequence, however; revealed a structural gene and a repressor gene which had significant (37 to 64%) sequence similarities with previously described classes of efflux-type tetracycline resistance genes from members of the family Enterobacteriaceae. The new determinant has been assigned to class H.

Related Genes
TET H Tc
MeSH Terms
Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA/genetics Escherichia coli/drug effects,genetics,metabolism Molecular Sequence Data Nucleic Acid Hybridization Pasteurella multocida/drug effects,genetics,metabolism Plasmids/genetics Tetracycline/administration & dosage,pharmacokinetics Tetracycline Resistance/genetics,physiology Turkeys
Chemicals
DNA Tetracycline
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hansen L M
Department of Veterinary Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616.
McMurry L M
Levy S B
Hirsh D C
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.37.12.2699
Published
1993-12-00
Pages
2699-705
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC192782
Subset
IM
Databases
GENBANK
V00792
External Links
PubMed source DOI: 10.1128/AAC.37.12.2699 PMC Full Text View journal details
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