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PMID: 8054280 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Progression and survival in prostatic adenocarcinoma: a comparison of clinical stage, Gleason grade, S-phase fraction and DNA ploidy.

British journal of cancer ·Vol. 70 ·No. 2 ·1994-08-00 ·Pages 309-14

Vesalainen S, Nordling S, Lipponen P, Talja M, Syrjänen K

Abstract

Clinical data were reviewed in 325 patients with prostatic adenocarcinoma followed up for a mean of 13 years. Paraffin-embedded tumour biopsy specimens from the primary tumours were available for flow cytometry (FCM) in 273 cases. Intra-tumour heterogeneity in DNA index (DI) was found in 4% of the tumours (54 cases were analysed). S-phase fraction (SPF) and DNA ploidy were significantly interrelated. Aneuploidy and high SPF were significantly related to both a high T category and high Gleason score. The progression in T1-2M0 tumours was related to Gleason score (P = 0.009), DNA ploidy (P = 0.006) and SPF (P = 0.007), while the Gleason score (P = 0.0013), DNA ploidy (P = 0.002) and SPF (P < 0.001) had prognostic value in univariate survival analysis. In the entire cohort, the T category (P < 0.001), M category (P < 0.001), Gleason score (P < 0.001), DNA ploidy (P < 0.001) and SPF (P < 0.001) were significant prognostic factors. In Cox's analysis, the M category (P < 0.001), Gleason score (P < 0.001), T category (P = 0.003), age (P = 0.001) and SPF (P = 0.087) were independently related to prognosis. In the T1-2M0 tumours, Gleason score (P < 0.001), T category (P = 0.022) and SPF (P = 0.058) were independent predictors. A novel classification system in which the DNA ploidy or SPF and the Gleason score were combined was found to be of significant prognostic value in all M0 tumours (P < 0.001). The results suggest that FCM can be used as an adjunct to conventional histological assessments for determination of the correct prognostic category in prostatic adenocarcinoma.

MeSH Terms
Adenocarcinoma/genetics,mortality,pathology Adult Aged Aged, 80 and over Analysis of Variance DNA, Neoplasm/genetics Flow Cytometry Follow-Up Studies Humans Male Middle Aged Multivariate Analysis Neoplasm Staging Ploidies Prognosis Prostatic Neoplasms/genetics,mortality,pathology S Phase/physiology
Chemicals
DNA, Neoplasm
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Vesalainen S
Department of Surgery, University of Kuopio, Finland.
Nordling S
Lipponen P
Talja M
Syrjänen K
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1994.298
Published
1994-08-00
Pages
309-14
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2033517
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1994.298 PMC Full Text View journal details
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