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PMID: 1517282 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Prognostic factors in WHO grade 2 transitional-cell bladder cancer (TCC); a novel two-grade classification system for TCC based on mitotic index.

Journal of cancer research and clinical oncology ·Vol. 118 ·No. 8 ·1992-00-00 ·Pages 615-20

Lipponen PK, Eskelinen MJ, Jauhiainen K, Harju E, Terho P, Haapasalo H

Abstract

A retrospective histological analysis has been carried out on 537 cases of transitional-cell bladder carcinoma, followed-up over a period of 9 years. In the first part of the study WHO grade 2 tumours were analysed and a number of independent factors predictive for survival identified. In a multivariate analysis the T category and M/V index (number of mitotic figures/mm2 neoplastic epithelium) were the most important prognostic factors. In a subsequent analysis of the whole series of 537 cases, overall the M/V index was not as important in predicting survival as the stage of the tumour. However, in superficial tumours (Ta-T1) subsequent analysis showed that the M/V index alone could be used to predict survival.

MeSH Terms
Aged Carcinoma, Transitional Cell/classification,genetics,pathology Chi-Square Distribution Cohort Studies Female Follow-Up Studies Humans Karyometry Male Mitotic Index Multivariate Analysis Prognosis Retrospective Studies Survival Analysis Survival Rate Urinary Bladder Neoplasms/classification,genetics,pathology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Lipponen P K
Department of Pathology, University of Kuopio, Finland.
Eskelinen M J
Jauhiainen K
Harju E
Terho P
Haapasalo H
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Article Info
Journal
Journal of cancer research and clinical oncology
Abbr.
J Cancer Res Clin Oncol
ISSN
0171-5216
DOI
10.1007/BF01211807
Published
1992-00-00
Pages
615-20
Language
English
Region
Germany
NLM ID
7902060
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01211807 View journal details
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