A membrane-associated autoantibody in a case of myasthenia gravis with chronic hepatitis.

Clinical and experimental immunology ·Vol. 25 ·No. 3 ·1976-09-00 ·Pages 383-8

Fairfax AJ, Doniach D, Wells CE

Abstract

A new antibody reacting with a cell membrane-related antigen is described in a patient with myasthenia gravis and chronic liver disease. The antibody gave a striking peripheral immunofluorescence in all cells tested and did not react with smooth muscle fibres, being distinct from anti-actin and anti-myosin antibodies. The antigen was widely distributed in human and animal tissues. The exact relationship of this antibody to the clinical condition is not obvious but its presence is further evidence of widespread disturbances of humoral immunity in myasthenia gravis.

MeSH Terms

Autoantibodies/analysis Cell Membrane/immunology Chronic Disease Female Fluorescent Antibody Technique Hepatitis/complications Humans Immunoglobulin G Middle Aged Muscle, Smooth/immunology Myasthenia Gravis/complications,immunology

Chemicals

Autoantibodies Immunoglobulin G

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fairfax A J

Doniach D

Wells C E

References (18)

18 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1976-09-00

Pages

383-8

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1541407

Subset

External Links

PubMed source PMC Full Text View journal details

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A membrane-associated autoantibody in a case of myasthenia gravis with chronic hepatitis.

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