An interplay of genetic and environmental factors in familial hepatitis and myasthenia gravis.

Gut ·Vol. 11 ·No. 10 ·1970-10-00 ·Pages 811-6

Whittingham S, Mackay IR, Kiss ZS

Abstract

A family is described in which there occurred two cases of the lupoid type of active chronic hepatitis with cirrhosis, one of chronic persistent hepatitis, and one of myasthenia gravis. The two cases of lupoid hepatitis were in the proposita, a schoolgirl aged 16 years, and her great-aunt aged 69 years whom she had never met. The case of myasthenia gravis was that of the father. The whole family, except the great-aunt, had been exposed to an epidemic of infectious hepatitis five years previously, and the girl and her brother had contracted this disease. The schoolgirl later developed active chronic hepatitis while her brother had chronic persistent hepatitis without immunological concomitants. APART FROM COINCIDENCE, SOME COMBINATION OF THREE PROCESSES WAS REQUIRED TO ACCOUNT FOR THE ILLNESSES IN THIS FAMILY: a genetic predisposition to chronic liver disease in particular, a genetic predisposition to autoimmune reactions in general, and a ;triggering' effect of infection with the hepatitis virus.

MeSH Terms

Adolescent Adult Aged Autoimmune Diseases/genetics Biopsy Chronic Disease Female Hepatitis/genetics Hepatitis A/genetics Humans Liver/pathology Liver Cirrhosis/genetics Male Myasthenia Gravis/genetics Pedigree

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Whittingham S

Mackay I R

Kiss Z S

References (29)

29 references, click to expand

The genetic factor in pernicious anaemia. A family study in patients with gastritis.
Lancet. 1969 May 10;1(7602):951-4 PMID: 4180811
Immunoglobulins, viruses, and speculation on their interrelationship in certain human and animal disease states.
Blood. 1968 Apr;31(4):522-35 PMID: 4171464
VIRAL INFECTION AND IDIOPATHIC AUTOIMMUNE DISEASES: A HYPOTHESIS.
Vox Sang. 1965 Jan-Feb;10:1-5 PMID: 14294357
A genetic approach to the pathogenesis of hepatic cirrhosis. A clinical and serological study.
Acta Med Scand. 1966 May;179(5):527-33 PMID: 4160726
AUTOANTIBODIES AND DISEASE.
Adv Immunol. 1964;27:351-95 PMID: 14333021
HEREDITARY HYPERGAMMAGLOBULINEMIA AND LUPOID HEPATITIS.
Acta Med Scand. 1965 Jun;177:751-9 PMID: 14334668
The prognosis of infective hepatitis; a preliminary account of a long-term follow-up.
Br Med J. 1958 Jun 7;1(5083):1315-7 PMID: 13536487
SYSTEMIC LUPUS ERYTHEMATOSUS, CIRRHOSIS AND ULCERATIVE COLITIS AFTER THYMECTOMY FOR MYASTHENIA GRAVIS.
N Engl J Med. 1964 Jan 30;270:229-31 PMID: 14072077
Immunologic deficiency, autoimmune disease, and lymphoma: observations, implications, and speculations.
Arthritis Rheum. 1966 Jun;9(3):464-72 PMID: 5938059
FAMILIAL CIRRHOSIS: A CLINICAL AND PATHOLOGICAL STUDY.
Ann Intern Med. 1964 Oct;61:667-79 PMID: 14217129
Persistent acute viral hepatitis.
Br Med J. 1962 Mar 31;1(5282):906-8 PMID: 13896394
"Auto-immune" chronic hepatitis.
Postgrad Med. 1967 Jan;41(1):72-83 PMID: 4166635
A FAMILY STUDY OF PERNICIOUS ANEMIA BY AN IMMUNOLOGIC METHOD.
J Lab Clin Med. 1964 Aug;64:177-87 PMID: 14202781
[Thymus gland tumor with lupoid hepatitis].
Schweiz Med Wochenschr. 1965 Oct 30;95(44):1492-4 PMID: 5880241
The incidence of residuals of viral hepatitis.
Gastroenterology. 1953 Dec;25(4):495-531 PMID: 13107947
Post-hepatitic cirrhosis of the liver; a follow-up study.
Ger Med Mon. 1967 Jul;12(7):305-11 PMID: 6065382
SYSTEMIC LUPUS ERYTHEMATOSUS FOLLOWING THYMECTOMY FOR MYSTHENIA GRAVIS. REPORT OF TWO CASES.
Lancet. 1963 Sep 28;2(7309):662-5 PMID: 14052027
THE TREATMENT OF ACUTE INFECTIOUS HEPATITIS. TEN-YEAR FOLLOW-UP STUDY OF THE EFFECTS OF DIET AND REST.
Am J Med. 1963 Sep;35:299-309 PMID: 14065871
ANTINUCLEAR ANTIBODIES IN FAMILIES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.
N Engl J Med. 1964 Jul 23;271:165-71 PMID: 14158353
THE THYMUS IN HEPATIC CIRRHOSIS.
J Clin Pathol. 1963 Sep;16:445-7 PMID: 14063330
Subacute hepatic necrosis and postnecrotic cirrhosis due to anicteric infections with the hepatitis virus.
Am J Med. 1958 Sep;25(3):333-58 PMID: 13571247
Australia antigen in chronic hepatitis in Australia.
Br Med J. 1970 Jan 31;1(5691):259-61 PMID: 5461278
FAMILY STUDIES IN SYSTEMIC LUPUS ERYTHEMATOSUS.
Acta Med Scand. 1964;176:SUPPL 416:1+ PMID: 14164860
ANTINUCLEAR FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUS. A CONSIDERATION OF THE IMMUNOFLUORESCENT METHOD OF DETECTING ANTINUCLEAR ANTIBODIES, WITH RESULTS OBTAINED IN A FAMILY STUDY.
Arthritis Rheum. 1964 Apr;7:119-27 PMID: 14150741
Laboratory methods for diagnosis of autoimmune disease.
Med J Aust. 1969 Jun 7;1(23):1200-5 PMID: 4183102
Prevalence and nature of hepatic disturbance following acute viral hepatitis with jaundice.
Ann Intern Med. 1955 Jul;43(1):1-32 PMID: 14388538
A family study of pernicious anaemia. II. Intrinsic factor secretion, vitamin B12 absorption and genetic aspects of gastric autoimmunity.
Br J Haematol. 1968 Feb;14(2):183-204 PMID: 5635601
Familial occurrence of the rheumatoid factor.
Arthritis Rheum. 1958 Oct;1(5):392-9 PMID: 13584230
Genetic studies on rheumatoid arthritis.
Ann Rheum Dis. 1958 Jun;17(2):160-8 PMID: 13559935

Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.11.10.811

Published

1970-10-00

Pages

811-6

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1553155

Subset

External Links

PubMed source DOI: 10.1136/gut.11.10.811 PMC Full Text View journal details

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An interplay of genetic and environmental factors in familial hepatitis and myasthenia gravis.

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