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PMID: 7835960 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A role for CD4+ T cells from orally immunized rats in enhanced clearance of Pseudomonas aeruginosa from the lung.

Immunology ·Vol. 83 ·No. 3 ·1994-11-00 ·Pages 362-9

Dunkley ML, Clancy RL, Cripps AW

Abstract

The role of gut-derived CD4+ T cells in clearance of Pseudomonas aeruginosa from the lung was studied by cell transfer experiments. Mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed P. aeruginosa or Helicobacter pylori, were transferred to naive rats which were subsequently challenged intra-tracheally with live P. aeruginosa. Recipients of unseparated mesenteric lymph node cells, purifed T cells or CD4+ T cells, from P. aeruginosa-immunized donors, all exhibited enhanced bacterial clearance from the airways compared to recipients of cells from unimmunized donors. Enhanced clearance by T cells was antigen-specific as no enhanced clearance was observed by transfer of cells from donors immunized with H. pylori.

MeSH Terms
Animals CD4-Positive T-Lymphocytes/immunology,transplantation Helicobacter pylori/immunology Immunization Lung/microbiology Lung Diseases/immunology Lymph Nodes/immunology Male Pseudomonas Infections/immunology Rats Specific Pathogen-Free Organisms T-Lymphocytes/immunology,transplantation
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dunkley M L
Faculty of Medicine and Health Science, University of Newcastle, Callaghan, New South Wales, Australia.
Clancy R L
Cripps A W
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1994-11-00
Pages
362-9
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1415036
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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