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PMID: 7729891 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Adherence of Candida albicans to a cell surface polysaccharide receptor on Streptococcus gordonii.

Infection and immunity ·Vol. 63 ·No. 5 ·1995-05-00 ·Pages 1827-34

Holmes AR, Gopal PK, Jenkinson HF

Abstract

Candida albicans ATCC 10261 and CA2 bound to cells of the oral bacteria Streptococcus gordonii, Streptococcus oralis, and Streptococcus sanguis when these bacteria were immobilized onto microtiter plate wells, but they did not bind to cells of Streptococcus mutans or Streptococcus salivarius. Cell wall polysaccharide was extracted with alkali from S. gordonii NCTC 7869, the streptococcal species to which C. albicans bound with highest affinity, and was effective in blocking the coaggregation of C. albicans and S. gordonii cells in the fluid phase. When fixed to microtiter plate wells, the S. gordonii polysaccharide was bound by all strains of C. albicans tested. The polysaccharide contained Rha, Glc, GalNAc, GlcNAc, and Gal and was related compositionally to previously characterized cell wall polysaccharides from strains of S. oralis and S. sanguis. The adherence of yeast cells to the immobilized polysaccharide was not inhibitable by a number of saccharides. Antiserum raised to the S. gordonii NCTC 7869 polysaccharide blocked adherence of C. albicans ATCC 10261 to the polysaccharide. The results identify a complex cell wall polysaccharide of S. gordonii as the coaggregation receptor for C. albicans. Adherent interactions of yeast cells with streptococci and other bacteria may be important for colonization of both hard and soft oral surfaces by C. albicans.

MeSH Terms
Candida albicans/physiology,ultrastructure Cell Adhesion/physiology Enzyme-Linked Immunosorbent Assay Microscopy, Electron, Scanning Monosaccharides/analysis Polysaccharides, Bacterial/chemistry,immunology,physiology Receptors, Cell Surface/chemistry,immunology,physiology Species Specificity Streptococcus/chemistry,physiology,ultrastructure
Chemicals
Monosaccharides Polysaccharides, Bacterial Receptors, Cell Surface
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Holmes A R
Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand.
Gopal P K
Jenkinson H F
References (39)
39 references, click to expand
  1. Adherence of Candida albicans to human salivary components adsorbed to hydroxylapatite.
    Microbiology. 1995 Jan;141 ( Pt 1):213-9 PMID: 7894715
  2. Binding of the extracellular matrix component entactin to Candida albicans.
    Infect Immun. 1994 Oct;62(10):4564-71 PMID: 7927722
  3. Adhere today, here tomorrow: oral bacterial adherence.
    J Bacteriol. 1993 Jun;175(11):3247-52 PMID: 8501028
  4. Characterization of Loosely Associated Material from the Cell Surface of Lactococcus lactis subsp. cremoris E8 and Its Phage-Resistant Variant Strain 398.
    Appl Environ Microbiol. 1993 Oct;59(10):3177-82 PMID: 16349058
  5. Actinomyces tissue specificity may depend on differences in receptor specificity for GalNAc beta-containing glycoconjugates.
    Infect Immun. 1992 Aug;60(8):3268-77 PMID: 1322371
  6. Adherence and receptor relationships of Candida albicans.
    Microbiol Rev. 1991 Mar;55(1):1-20 PMID: 2030668
  7. Yeasts, enteric rods and pseudomonads in the subgingival flora of severe adult periodontitis.
    Oral Microbiol Immunol. 1988 Jun;3(2):47-52 PMID: 3268751
  8. Chemical definition of an epitope/adhesin molecule on Candida albicans.
    J Biol Chem. 1993 Aug 25;268(24):18293-9 PMID: 7688744
  9. Role of specific determinants in mannan of Candida albicans serotype A in adherence to human buccal epithelial cells.
    Infect Immun. 1992 Jun;60(6):2493-9 PMID: 1375200
  10. The fibronectin adhesin of Candida albicans.
    Infect Immun. 1994 Oct;62(10):4679-81 PMID: 7927741
  11. Identification of a 58-kilodalton cell surface fibrinogen-binding mannoprotein from Candida albicans.
    Infect Immun. 1992 Oct;60(10):4221-9 PMID: 1398933
  12. Purification and characterization of a Bacteroides loeschei adhesin that interacts with procaryotic and eucaryotic cells.
    J Bacteriol. 1990 May;172(5):2527-34 PMID: 1970562
  13. Coaggregation of Streptococcus sanguis and other streptococci with Candida albicans.
    Infect Immun. 1990 May;58(5):1429-36 PMID: 2182544
  14. Complete structure of the adhesin receptor polysaccharide of Streptococcus oralis ATCC 55229 (Streptococcus sanguis H1).
    Biochemistry. 1992 Nov 10;31(44):10741-6 PMID: 1420190
  15. Molecules of Streptococcus gordonii that bind to Porphyromonas gingivalis.
    Microbiology. 1994 Apr;140 ( Pt 4):867-72 PMID: 8012603
  16. Nutritional factors determine germ tube formation in Candida albicans.
    J Med Vet Mycol. 1988 Apr;26(2):127-31 PMID: 3047355
  17. Multigeneric aggregations among oral bacteria: a network of independent cell-to-cell interactions.
    J Bacteriol. 1986 Nov;168(2):851-9 PMID: 3782029
  18. Laminin receptors on Candida albicans germ tubes.
    Infect Immun. 1990 Jan;58(1):48-54 PMID: 2136734
  19. In vitro inhibition of adhesion of Candida albicans clinical isolates to human buccal epithelial cells by Fuc alpha 1----2Gal beta-bearing complex carbohydrates.
    Infect Immun. 1991 May;59(5):1605-13 PMID: 2019432
  20. Cell-surface-associated polypeptides CshA and CshB of high molecular mass are colonization determinants in the oral bacterium Streptococcus gordonii.
    Mol Microbiol. 1994 Nov;14(4):743-54 PMID: 7891560
  21. Identification and characterization of a Candida albicans-binding proteoglycan secreted from rat submandibular salivary glands.
    Infect Immun. 1994 Mar;62(3):828-36 PMID: 8112852
  22. Specificity of coaggregation reactions between human oral streptococci and strains of Actinomyces viscosus or Actinomyces naeslundii.
    Infect Immun. 1979 Jun;24(3):742-52 PMID: 468376
  23. Cell-surface proteins of Streptococcus sanguis associated with cell hydrophobicity and coaggregation properties.
    J Gen Microbiol. 1986 Jun;132(6):1575-89 PMID: 2433382
  24. Coaggregation: specific adherence among human oral plaque bacteria.
    FASEB J. 1993 Mar;7(5):406-13 PMID: 8462782
  25. Molecular mimicry in Candida albicans. Role of an integrin analogue in adhesion of the yeast to human endothelium.
    J Clin Invest. 1991 Jun;87(6):1896-902 PMID: 2040685
  26. A polysaccharide from Streptococcus sanguis 34 that inhibits coaggregation of S. sanguis 34 with Actinomyces viscosus T14V.
    J Bacteriol. 1988 May;170(5):2229-35 PMID: 3360742
  27. Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to the glycosphingolipid lactosylceramide (Gal beta 1-4Glc beta 1-1Cer), a possible adhesion receptor for yeasts.
    Infect Immun. 1990 Jul;58(7):2085-90 PMID: 2194958
  28. Salivary-agglutinin-mediated adherence of Streptococcus mutans to early plaque bacteria.
    Infect Immun. 1991 Oct;59(10):3446-50 PMID: 1894355
  29. Mutants of Actinomyces viscosus T14V lacking type 1, type 2, or both types of fimbriae.
    Infect Immun. 1988 Nov;56(11):2984-9 PMID: 2902012
  30. Characterization of Streptococcus gordonii (S. sanguis) PK488 adhesin-mediated coaggregation with Actinomyces naeslundii PK606.
    Infect Immun. 1990 Sep;58(9):3064-72 PMID: 2387635
  31. Human submandibular-sublingual saliva promotes adhesion of Candida albicans to polymethylmethacrylate.
    Infect Immun. 1993 Jun;61(6):2644-52 PMID: 8500903
  32. Mutants of Streptococcus gordonii Challis over-producing glucosyltransferase.
    J Gen Microbiol. 1991 Mar;137(3):483-9 PMID: 1851801
  33. Coaggregation of oral Candida isolates with bacteria from bone marrow transplant recipients.
    J Clin Microbiol. 1990 Dec;28(12):2621-6 PMID: 2279992
  34. Fimbria-mediated adherence of Candida albicans to glycosphingolipid receptors on human buccal epithelial cells.
    Infect Immun. 1994 Jul;62(7):2843-8 PMID: 8005674
  35. Inactivation of the gene encoding surface protein SspA in Streptococcus gordonii DL1 affects cell interactions with human salivary agglutinin and oral actinomyces.
    Infect Immun. 1993 Aug;61(8):3199-208 PMID: 8335350
  36. Isolation of a coaggregation-inhibiting cell wall polysaccharide from Streptococcus sanguis H1.
    J Bacteriol. 1989 Jul;171(7):4019-25 PMID: 2661543
  37. Analysis of Candida albicans adhesion to salivary mucin.
    Infect Immun. 1993 May;61(5):1940-9 PMID: 8478083
  38. Nucleotide sequence of the Streptococcus gordonii PK488 coaggregation adhesin gene, scaA, and ATP-binding cassette.
    Infect Immun. 1994 Oct;62(10):4469-80 PMID: 7927711
  39. Characterization of a fucoside-binding adhesin of Candida albicans.
    Infect Immun. 1992 Nov;60(11):4734-9 PMID: 1398983
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.63.5.1827-1834.1995
Published
1995-05-00
Pages
1827-34
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC173231
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.63.5.1827-1834.1995 PMC Full Text View journal details
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