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PMID: 7634156 Published · ppublish English Journal Article Review

Zonation of metabolism and gene expression in liver.

Histochemistry and cell biology ·Vol. 103 ·No. 2 ·1995-02-00 ·Pages 81-91

Jungermann K

Abstract

暂无摘要

MeSH Terms
Animals Gene Expression/physiology Humans Liver/anatomy & histology,metabolism
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Jungermann K
Institut für Biochemie und Molekulare Zellbiologie, Georg-August Universität, Göttingen, Germany.
References (84)
84 references, click to expand
  1. Liver architecture.
    Enzyme. 1992;46(1-3):8-32 PMID: 1289084
  2. Functional hepatocellular heterogeneity for the production of plasma proteins.
    Enzyme. 1992;46(1-3):139-54 PMID: 1289079
  3. Pericentral expression pattern of glucokinase mRNA in the rat liver lobulus.
    FEBS Lett. 1991 Aug 5;287(1-2):47-52 PMID: 1879536
  4. Functional hepatocellular heterogeneity.
    Hepatology. 1982 May-Jun;2(3):385-95 PMID: 7042508
  5. [Metabolic zoning of the human liver parenchyma in comparison with various mammals].
    Acta Histochem Suppl. 1985;31:79-81 PMID: 2991985
  6. Heterogeneous reciprocal localization of fructose-1,6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue.
    FEBS Lett. 1977 Nov 15;83(2):272-6 PMID: 201494
  7. Biologically active products of stimulated liver macrophages (Kupffer cells).
    Eur J Biochem. 1990 Sep 11;192(2):245-61 PMID: 2170121
  8. The distribution of glucose-6-phosphatase in the liver and kidney of the mouse.
    J Histochem Cytochem. 1953 Nov;1(6):429-35 PMID: 13118124
  9. Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P-450b and P-450e gene expression after phenobarbital.
    J Clin Invest. 1988 Aug;82(2):658-66 PMID: 3042808
  10. Signal propagation via gap junctions, a key step in the regulation of liver metabolism by the sympathetic hepatic nerves.
    FEBS Lett. 1992 Apr 27;301(3):265-70 PMID: 1577164
  11. Hepatocyte heterogeneity in response to extracellular ATP.
    Eur J Biochem. 1987 Dec 15;169(3):645-50 PMID: 3691513
  12. Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice.
    J Biol Chem. 1990 Dec 25;265(36):22371-9 PMID: 1702419
  13. Immunocytochemical localization of glucocorticoid receptor in target cells.
    Endocrinology. 1984 Nov;115(5):1984-9 PMID: 6208016
  14. Inhibition of glucose production during hepatic nerve stimulation in regenerating rat liver perfused in situ. Possible involvement of gap junctions in the action of sympathetic nerves.
    Eur J Biochem. 1991 Aug 15;200(1):69-74 PMID: 1652441
  15. The pattern of glycogen distribution in the liver.
    Am J Anat. 1968 Jan;122(1):57-72 PMID: 4172633
  16. Predominant localization of phosphoenolpyruvate carboxykinase mRNA in the periportal zone of rat liver parenchyma demonstrated by in situ hybridization.
    FEBS Lett. 1989 May 8;248(1-2):188-94 PMID: 2721676
  17. Autoregulatory shift from fructolysis to lactate gluconeogenisis in rat hepatocyte suspensions. The problem of metabolic zonation of liver parenchyma.
    Hoppe Seylers Z Physiol Chem. 1976 Mar;357(3):359-75 PMID: 955564
  18. Integration of function in the hepatic acinus: intercellular communication in neural and humoral control of liver metabolism.
    Prog Liver Dis. 1994;12:19-46 PMID: 7746874
  19. Modulation of the glucagon-dependent induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by arterial and venous oxygen concentrations in hepatocyte cultures.
    Eur J Biochem. 1981 Oct;119(3):657-61 PMID: 6118270
  20. Hepatocyte heterogeneity in the metabolism of carbohydrates.
    Enzyme. 1992;46(1-3):33-58 PMID: 1289081
  21. Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. Evidence for a heme protein as oxygen sensor.
    FEBS Lett. 1992 Oct 26;311(3):251-5 PMID: 1397323
  22. Functional implications of liver cell heterogeneity.
    Gastroenterology. 1981 Feb;80(2):393-403 PMID: 7004997
  23. Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures.
    Eur J Biochem. 1991 Jun 15;198(3):635-9 PMID: 2050145
  24. Hepatocyte heterogeneity in bile formation and hepatobiliary transport of drugs.
    Enzyme. 1992;46(1-3):94-138 PMID: 1289085
  25. Extracellular matrix gradients in the space of Disse: relevance to liver biology.
    Hepatology. 1992 Jun;15(6):1198-203 PMID: 1592356
  26. The circadian rhythm of intra-acinar profiles of alcohol dehydrogenase activity in rat liver: a microquantitative study.
    Histochem J. 1990 Aug;22(8):395-400 PMID: 2228728
  27. Nervous control of liver metabolism and hemodynamics.
    Eur J Biochem. 1992 Jul 15;207(2):399-411 PMID: 1633798
  28. [Observations on the pathophysiology of liver structure].
    Klin Wochenschr. 1960 Jun 15;38:561-77 PMID: 14436279
  29. Dynamics of liver glycogen: the topochemistry of glycogen synthesis, glycogen content and glycogenolysis under the experimental conditions of glycogen accumulation and depletion.
    Histochemistry. 1975 Dec 8;45(3):237-54 PMID: 814113
  30. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein.
    Science. 1988 Dec 9;242(4884):1412-5 PMID: 2849206
  31. Reciprocal distribution of hexokinase and glucokinase in the periportal and perivenous zone of the rat liver acinus.
    Hoppe Seylers Z Physiol Chem. 1982 Apr;363(4):375-80 PMID: 7076132
  32. Metabolic heterogeneity of liver parenchymal cells.
    Essays Biochem. 1990;25:83-136 PMID: 2199193
  33. Zonal liver cell heterogeneity.
    Enzyme. 1992;46(1-3):5-7 PMID: 1289082
  34. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.
    Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10553-7 PMID: 1961720
  35. Predominant periportal expression of the phosphoenolpyruvate carboxykinase and tyrosine aminotransferase genes in rat liver. Dynamics during the daily feeding rhythm and starvation-refeeding cycle demonstrated by in situ hybridization.
    Histochemistry. 1990;94(6):637-44 PMID: 1980679
  36. Localization of cells producing erythropoietin in murine liver by in situ hybridization.
    Blood. 1991 Jun 1;77(11):2497-503 PMID: 2039831
  37. Histochemical distribution pattern of respiratory enzymes in the liver lobule.
    Science. 1957 Mar 15;125(3246):501-3 PMID: 13408998
  38. Regulatory elements of the erythropoietin gene.
    Blood. 1991 Jan 15;77(2):278-85 PMID: 1985694
  39. Long-term effects of physiological oxygen concentrations on glycolysis and gluconeogenesis in hepatocyte cultures.
    Eur J Biochem. 1985 Sep 2;151(2):299-303 PMID: 4029136
  40. Differential effects of human anaphylatoxin C3a on glucose output and flow in rat liver during orthograde and retrograde perfusion: the periportal scavenger cell hypothesis.
    Biochem Biophys Res Commun. 1991 May 15;176(3):1218-26 PMID: 2039507
  41. Hexokinase and glucokinase distribution in the liver lobule.
    J Histochem Cytochem. 1980 Jun;28(6):579-81 PMID: 7391551
  42. Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes.
    J Cell Biol. 1989 Mar;108(3):1039-51 PMID: 2537831
  43. Sublobular compartmentation of pharmacologic events (SCOPE): metabolic fluxes in periportal and pericentral regions of the liver lobule.
    Hepatology. 1985 Jan-Feb;5(1):144-51 PMID: 3967857
  44. Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.
    EMBO J. 1983;2(4):567-70 PMID: 6138251
  45. Distribution of glutamine synthetase and carbamoyl-phosphate synthetase I in vertebrate liver.
    Proc Natl Acad Sci U S A. 1988 Jan;85(1):160-4 PMID: 2893372
  46. Experimental evidence that the physiological position of the liver within the circulation is not a major determinant of zonation of gene expression.
    Hepatology. 1993 Nov;18(5):1144-53 PMID: 8225221
  47. Methods for the study of liver cell heterogeneity.
    Histochem J. 1989 Sep-Oct;21(9-10):517-29 PMID: 2687211
  48. Predominant periportal expression of the phosphoenolpyruvate carboxykinase gene in liver of fed and fasted mice, hamsters and rats studied by in situ hybridization.
    Histochemistry. 1993 Apr;99(4):303-9 PMID: 8500994
  49. Positional and developmental regulation of glutamine synthetase expression in mouse liver.
    Mol Cell Biol. 1988 Nov;8(11):4966-71 PMID: 2905422
  50. Detection of mRNAs present at low concentrations in rat liver by in situ hybridization: application to the study of metabolic regulation and azo dye hepatocarcinogenesis.
    J Histochem Cytochem. 1987 May;35(5):559-63 PMID: 3104450
  51. Induction in primary culture of 'gluconeogenic' and 'glycolytic' hepatocytes resembling periportal and perivenous cells.
    Eur J Biochem. 1982 Aug;126(2):271-8 PMID: 6751822
  52. Hepatocyte heterogeneity in the metabolism of amino acids and ammonia.
    Enzyme. 1992;46(1-3):72-93 PMID: 1289083
  53. Alteration with dietary state of the activity and zonal distribution of adenylate cyclase stimulated by glucagon, fluoride and forskolin in microdissected rat liver tissue.
    Eur J Biochem. 1984 Dec 17;145(3):499-504 PMID: 6542521
  54. Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication.
    Hepatology. 1993 Nov;18(5):1202-7 PMID: 7693574
  55. Distribution of cyclic AMP phosphodiesterase in microdissected periportal and perivenous rat liver tissue with different dietary states.
    Histochemistry. 1991;96(1):87-92 PMID: 1718930
  56. Histochemical and immunohistochemical localization of hexokinase isoenzymes in normal rat liver.
    Histochem J. 1984 Oct;16(10):1099-111 PMID: 6094398
  57. Liver fibrosis: perspectives in pathobiochemical research and clinical outlook.
    Eur J Clin Chem Clin Biochem. 1991 May;29(5):293-311 PMID: 1892952
  58. Zonal expression of the glucokinase gene in rat liver. Dynamics during the daily feeding rhythm and starvation-refeeding cycle demonstrated by in situ hybridization.
    Histochemistry. 1993 Feb;99(2):133-40 PMID: 8478214
  59. A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures.
    Biochem Biophys Res Commun. 1993 Sep 15;195(2):792-8 PMID: 8373414
  60. Glycogen synthesis via the indirect gluconeogenic pathway in the periportal and via the direct glucose utilizing pathway in the perivenous zone of perfused rat liver.
    Histochemistry. 1988;89(3):253-60 PMID: 3403300
  61. Functional heterogeneity of rat liver parenchyma and of isolated hepatocytes.
    FEBS Lett. 1975 Sep 1;57(1):83-8 PMID: 170133
  62. Liver cell heterogeneity: functions of non-parenchymal cells.
    Enzyme. 1992;46(1-3):155-68 PMID: 1289080
  63. Heterogeneous distribution of glucose-6-phosphatase in microdissected periportal and perivenous rat liver tissue.
    FEBS Lett. 1977 Apr 15;76(2):226-30 PMID: 193728
  64. Intrasplenic transplantation of isolated periportal and perivenous hepatocytes as a long-term system for study of liver-specific gene expression.
    Hepatology. 1994 Apr;19(4):989-98 PMID: 7908009
  65. The intra-acinar distribution patterns of alcohol-dehydrogenase activity in the liver of juvenile, castrated and testosterone-treated rats.
    Biol Chem Hoppe Seyler. 1987 Apr;368(4):315-21 PMID: 3606818
  66. Distribution of pyruvate kinase type L and M2 in microdissected periportal and perivenous rat liver tissue with different dietary states.
    Hoppe Seylers Z Physiol Chem. 1983 Oct;364(10):1447-53 PMID: 6642430
  67. Heterogeneous expression of glutamine synthetase mRNA in rat liver parenchyma revealed by in situ hybridization and Northern blot analysis of RNA from periportal and perivenous hepatocytes.
    FEBS Lett. 1988 Dec 5;241(1-2):89-93 PMID: 2904380
  68. Hepatocyte heterogeneity: the coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulation.
    Hepatology. 1989 Jan;9(1):154-60 PMID: 2642292
  69. Cell heterogeneity within the hepatic lobule of the rat: staining reactions.
    J Histochem Cytochem. 1959 Jul;7(4):240-4 PMID: 13664971
  70. Immunohistochemical localization of carbamoyl-phosphate synthetase (ammonia) in adult rat liver; evidence for a heterogeneous distribution.
    J Histochem Cytochem. 1984 Jun;32(6):557-64 PMID: 6373912
  71. Mechanism of the inhibition by insulin of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures. Action on gene transcription, mRNA level and -stability as well as hysteresis effect.
    Biol Chem Hoppe Seyler. 1990 May;371(5):395-402 PMID: 2198886
  72. Hepatocyte heterogeneity in the metabolism of fatty acids: discrepancies on zonation of acetyl-CoA carboxylase.
    Enzyme. 1992;46(1-3):59-71 PMID: 1363231
  73. Changes in distribution of enzymes within the liver lobule during adaptive increases.
    J Histochem Cytochem. 1972 Feb;20(2):107-11 PMID: 4400699
  74. Hepatocyte heterogeneity and liver function.
    Revis Biol Celular. 1989;19:1-161 PMID: 2672142
  75. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
    Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5680-4 PMID: 2062846
  76. Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.
    J Cell Sci. 1994 Jan;107 ( Pt 1):83-95 PMID: 8175925
  77. Complementary distribution of carbamoylphosphate synthetase (ammonia) and glutamine synthetase in rat liver acinus is regulated at a pretranslational level.
    J Histochem Cytochem. 1988 Jul;36(7):751-5 PMID: 2898495
  78. Hepatocyte heterogeneity in response to icosanoids. The perivenous scavenger cell hypothesis.
    Eur J Biochem. 1988 Aug 1;175(2):395-403 PMID: 3165342
  79. Heterogeneous (positional) expression of hepatic glutamine synthetase: features, regulation and implications for hepatocarcinogenesis.
    Adv Enzyme Regul. 1994;34:27-56 PMID: 7942280
  80. Diurnal variation of the serine dehydratase mRNA level in rat liver.
    Arch Biochem Biophys. 1994 Jan;308(1):285-91 PMID: 8311466
  81. Heterogeneous distribution of phosphoenolpyruvate carboxykinase in rat liver parenchyma, isolated, and cultured hepatocytes.
    Eur J Cell Biol. 1982 Aug;28(1):47-53 PMID: 6751828
  82. Liver cell heterogeneity. The distribution of pyruvate kinase and phosphoenolpyruvate carboxykinase (GTP) in the liver lobule of fed and starved rats.
    Hoppe Seylers Z Physiol Chem. 1976 Dec;357(12):1793-800 PMID: 1017801
  83. The compartmentation of glycolytic and gluconeogenic enzymes in rat kidney and liver and its significance to renal and hepatic metabolism.
    Histochem J. 1986 Jan;18(1):45-53 PMID: 2423478
  84. Zonation of glucokinase in rat liver changes during postnatal development.
    FEBS Lett. 1993 Aug 9;328(1-2):119-24 PMID: 8344416
Article Info
Journal
Histochemistry and cell biology
Abbr.
Histochem Cell Biol
ISSN
0948-6143
DOI
10.1007/BF01454004
Published
1995-02-00
Pages
81-91
Language
English
Region
Germany
NLM ID
9506663
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01454004 View journal details
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