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PMID: 7317007 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Increased muscle calcium. A possible cause of mitochondrial dysfunction and cellular necrosis in denervated rat skeletal muscle.

The Biochemical journal ·Vol. 196 ·No. 3 ·1981-06-15 ·Pages 663-7

Joffe M, Savage N, Isaacs H

Abstract

Mitochondrial preparations derived from denervated rat skeletal muscle and paired controls were characterized with respect to their ability to take up externally added Ca2+. The denervated and control muscle homogenates and mitochondrial [Ca2+] were also determined. Our data indicate that the denervated mitochondria are able to take up less Ca2+ than the controls before uncoupling occurs. This defect is associated with elevated [Ca2+] in homogenate and mitochondrial fractions in the denervated state. The causal relationship between Ca2+ overload, mitochondrial functional damage and cell necrosis is discussed.

MeSH Terms
Animals Calcium/metabolism Female In Vitro Techniques Mitochondria, Muscle/metabolism Muscle Denervation Muscles/metabolism,pathology Necrosis Oxygen Consumption Rats
Chemicals
Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Joffe M
Savage N
Isaacs H
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39 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1960663
Published
1981-06-15
Pages
663-7
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1163083
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1960663 PMC Full Text View journal details
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