The effect of the hypocholesterolemic drug clofibrate on liver mitochondrial biogenesis. A role for neutral mitochondrial proteases.

Acid Phosphatase/metabolism Animals Arginine/metabolism Carbon Radioisotopes Clofibrate/pharmacology Cytochrome Reductases/metabolism DNA/metabolism Electron Transport Complex IV/metabolism Hepatectomy Leucine/metabolism Liver/metabolism,physiology Lysosomes/drug effects,metabolism Malate Dehydrogenase/metabolism Male Methionine/metabolism Mitochondria, Liver/drug effects,enzymology,metabolism Mixed Function Oxygenases/metabolism Monoamine Oxidase/metabolism Oxygen Consumption/drug effects Protease Inhibitors RNA/metabolism Rats Rotenone/pharmacology Sulfur Radioisotopes

Carbon Radioisotopes Protease Inhibitors Sulfur Radioisotopes Rotenone RNA DNA Arginine Methionine Mixed Function Oxygenases Malate Dehydrogenase Monoamine Oxidase Cytochrome Reductases Electron Transport Complex IV Acid Phosphatase Leucine Clofibrate