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PMID: 7294023 Published · ppublish English Case Reports Journal Article

Unstable familial translocations: A t(11;22)mat inherited as a t(11;15).

American journal of human genetics ·Vol. 33 ·No. 5 ·1981-09-00 ·Pages 745-51

Tomkins DJ

Abstract

Unusual inheritance of a reciprocal translocation, t(11;22)(p11;p12)mat was discovered in a family with one daughter having a different translocation, t(11;15)(p11;p12). Another daughter inherited the same translocation as her mother. The breakpoints through the nucleolar organizing regions (NORs) of chromosomes 15 and 22 were determined by silver staining. A review of the literature has demonstrated that such unstable familial translocations are very rare and can occur either in mitosis or meiosis. They usually involve exchanges between centromeres, telomeres, or NORs.

MeSH Terms
Abortion, Habitual/genetics Chromosomes, Human, 13-15 Chromosomes, Human, 21-22 and Y Chromosomes, Human, 6-12 and X Female Humans Karyotyping Male Phenotype Pregnancy Translocation, Genetic
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Tomkins D J
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21 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1981-09-00
Pages
745-51
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685141
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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