Distribution of spontaneous chromosome breaks in human chromosomes.

Human genetics ·Vol. 32 ·No. 2 ·1976-05-19 ·Pages 143-8

Aula P, von Koskull H

Abstract

Localization of chromosome breaks in human chromosomes was analyzed in 264 peripheral lymphocyte cultures. Three hundred and sixty-nine chromosome breaks could be exactly localized to a chromosome band or region of the Paris Conference nomenclature. The distribution of breaks in the chromosome regions was found to be nonrandom. Chromosome 3 alone had 23% of the breaks and region 3p2 had 13% of the total breaks. Some other chromosome regions, such as 5p1, 9q1, 14q2, and 16q2 also displayed clustering of breaks. Sex chromosomes had less breaks than expected. Spontaneous chromosome breaks were almost exclusively located in the lightly stained G bands.

MeSH Terms

Chromosome Aberrations Chromosomes, Human, 1-3 Chromosomes, Human, 13-15 Chromosomes, Human, 16-18 Chromosomes, Human, 4-5 Chromosomes, Human, 6-12 and X Humans Karyotyping Lymphocytes/ultrastructure Sex Chromosomes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Aula P

von Koskull H

References (16)

16 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00291497

Published

1976-05-19

Pages

143-8

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00291497 View journal details

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Distribution of spontaneous chromosome breaks in human chromosomes.

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