The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects.

Humangenetik ·Vol. 28 ·No. 3 ·1975-07-23 ·Pages 221-31

Cooke P, Seabright M, Wheeler M

Abstract

The distribution of X-ray induced aberrations between trypsin-banded regions within human chromosomes has been studied in over a thousand cells from normal and abnormal individuals. An analysis of this data has been performed for each type of aberration separately, taking into account the relative amount of material at risk in reach region. A number of significant deviations from expectation were detected but many of these could be explained in terms of the failure of detection of some aberrations.

MeSH Terms

Chromosome Aberrations Chromosome Inversion Chromosomes/radiation effects Female Humans Male Radiation Genetics Staining and Labeling/methods Translocation, Genetic Trypsin X-Rays

Chemicals

Trypsin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Cooke P

Seabright M

Wheeler M

References (9)

9 references, click to expand

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Exp Cell Res. 1972 Dec;75(2):541-3 PMID: 4644257
Preferential location of x-ray induced chromosome breakage in the R-bands of human chromosomes.
Hereditas. 1973;74(1):57-67 PMID: 4758985
High resolution studies on the pattern of induced exchanges in the human karyotype.
Chromosoma. 1973;40(4):333-46 PMID: 4693087
Distortion hypothesis: an alternative to a limited number of sites for radiation-induced chromosome exchange.
J Theor Biol. 1969 Mar;22(3):493-514 PMID: 5803334
Incidence and mutation rates of structural rearrangements of the autosomes in man.
Ann Hum Genet. 1972 Mar;35(3):301-19 PMID: 4262869
Randomness in the formation of radiation-indued chromosome aberrations.
Genetics. 1965 Dec;52(6):1329-34 PMID: 5882200
An analysis of the break points of structural rearrangements in man.
J Med Genet. 1974 Mar;11(1):50-64 PMID: 4134839
The sites of radiation induced-breakage in human lymphocyte chromosomes, determined by quinacrine fluorescence.
Mutat Res. 1973 Jun;18(3):325-31 PMID: 4712311
A rapid banding technique for human chromosomes.
Lancet. 1971 Oct 30;2(7731):971-2 PMID: 4107917

Article Info

Journal

Humangenetik

Abbr.

Humangenetik

ISSN

0018-7348

DOI

10.1007/BF00278548

Published

1975-07-23

Pages

221-31

Language

English

Region

Germany

NLM ID

7607154

Subset

External Links

PubMed source DOI: 10.1007/BF00278548

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The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects.

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