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PMID: 7241660 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Reovirus inhibition of cellular DNA synthesis: role of the S1 gene.

Journal of virology ·Vol. 38 ·No. 1 ·1981-04-00 ·Pages 389-92

Sharpe AH, Fields BN

Abstract

Type 3 reovirus inhibits L cell DNA synthesis, whereas type 1 reovirus exerts little or no effect on L cell DNA synthesis. By using recombinant viruses containing both type 1 and type 3 double-standard RNA segments, we determined that one double-stranded RNA segment, the reovirus type 3 S1 double-stranded RNA segment which encodes the viral hemagglutinin, segregates with and is responsible for the capacity of reovirus type 3 to inhibit L cell DNA synthesis.

MeSH Terms
Animals Cell Transformation, Viral DNA/biosynthesis Genes, Viral L Cells Mice Reoviridae/genetics,radiation effects Ultraviolet Rays
Chemicals
DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sharpe A H
Fields B N
References (20)
20 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.38.1.389-392.1981
Published
1981-04-00
Pages
389-92
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC171164
Subset
IM
Grants
NIGMS NIH HHS · 5-T32 GMO 7916 · United States
NCI NIH HHS · CA09031-04 · United States
NIAID NIH HHS · R0I AI 13178 · United States
External Links
PubMed source DOI: 10.1128/JVI.38.1.389-392.1981 PMC Full Text View journal details
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