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PMID: 218202 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 1 ·1979-01-00 ·Pages 442-6

Finberg R, Weiner HL, Fields BN, Benacerraf B, Burakoff SJ

Abstract

Cytotoxic T lymphocytes (CTLs) can be generated if spleen cells from reovirus-infected mice are stimulated in vitro with syngeneic reovirus-infected cells. These cytolytic effector cells demonstrate: (i) serotype specificity (i.e., maximal cytolytic activity is observed on target cells infected with the serotype used to induce the CTLs) and (ii) H-2 restriction. The SI gene was shown to be the predominant viral gene determining the specificity of the cytotoxic T cells. This genome segment has previously been demonstrated to encode the viral hemagglutinin and determines reovirus cell tropism in the nervous system.

MeSH Terms
Animals Cytotoxicity, Immunologic Genes, MHC Class II Genes, Viral H-2 Antigens Major Histocompatibility Complex Mice Reoviridae/genetics Reoviridae Infections/immunology T-Lymphocytes/immunology
Chemicals
H-2 Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Finberg R
Weiner H L
Fields B N
Benacerraf B
Burakoff S J
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25 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.1.442
Published
1979-01-00
Pages
442-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC382956
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.1.442 PMC Full Text View journal details
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