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PMID: 1082140 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 2 ·1976-02-00 ·Pages 625-9

Burakoff SJ, Germain RN, Dorf ME, Benacerrah B

Abstract

The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured with trinitrophenyl-derivatized syngeneic cells, generate cytolytic T cells that lyse most effectively tumor or spleen targets that are trinitrophenyl-derivatized and H-2 identical to the sensitizing cell. Cytolysis is inhibited by alloantisera to the K and/or D specificities of the target cells and by anti-dinitrophenyl antisera. Cytolic cells generated in this manner are also able to lyse, though less efficiently, trinitrophenyl-derivatized tumor and spleen targets that do not share products of the K and D loci with the sensitizing cell, and this cytolysis is also blocked by alloantisera directed to the H-2 serological specificities of such targets.

MeSH Terms

Animals Antigen-Antibody Reactions Cross Reactions Cytotoxicity Tests, Immunologic Histocompatibility Antigens Isoantibodies Mice Neoplasms, Experimental/immunology Nitrobenzenes/immunology Spleen/immunology T-Lymphocytes/immunology

Chemicals

Histocompatibility Antigens Isoantibodies Nitrobenzenes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Burakoff S J

Germain R N

Dorf M E

Benacerrah B

References (18)

18 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.73.2.625

Published

1976-02-00

Pages

625-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC335964

Subset

External Links

PubMed source DOI: 10.1073/pnas.73.2.625 PMC Full Text View journal details

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Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.

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