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PMID: 7216322 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The location of C2, C4, and BF relative to HLA-B and HLA-D.

Immunogenetics ·Vol. 12 ·No. 5-6 ·1981-03-01 ·Pages 473-83

Raum DD, Awdeh ZL, Glass D, Yunis E, Alper CA

Abstract

The loci for HLA-A,B,C,D, and DR are known to be closely linked to the structural loci for the complement components C2, BF, and the duplicated loci for C4, C4A and C4B. Conflicting evidence has been presented for the order of these genes. However, new techniques have made possible identification of markers in the HLA-D and C4 region for nearly all identified haplotypes. In our population we have confirmed five HLA-B-D crossovers and in each case informative allotypes of C2, BF, or C4A and C4B segregated with HLA-D or DR suggesting that the loci for these proteins lie close to HLA-D and DR. These findings may be of importance for resolving problems encountered in the assignment of HLA-D alleles.

MeSH Terms
Complement C2/genetics,immunology Complement C4/genetics,immunology Crossing Over, Genetic Genetic Linkage HLA Antigens/genetics Humans Pedigree
Chemicals
Complement C2 Complement C4 HLA Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Raum D D
Awdeh Z L
Glass D
Yunis E
Alper C A
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF01561689
Published
1981-03-01
Pages
473-83
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NIAID NIH HHS · AI14157 · United States
NIAID NIH HHS · AI15033 · United States
NIADDK NIH HHS · AM16392 · United States
External Links
PubMed source DOI: 10.1007/BF01561689 View journal details
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