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PMID: 7424908 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic polymorphism of human plasminogen.

American journal of human genetics ·Vol. 32 ·No. 5 ·1980-09-00 ·Pages 681-9

Raum D, Marcus D, Alper CA

Abstract

Using isoelectric focusing (IEF) in polyacrylamide gel of neuraminidase-treated serum or plasma samples and immunofixation or caseinolytic overlay after urokinase activation of gels, a common genetic polymorphism in human plasminogen has been delineated. Two alleles PLGN*A and PLGN*B, were observed with gene frequencies in whites of .69 and .30; in Orientals of .96 and .03; and in blacks of .80 and .18. Several rare alleles were also found. The distribution of phenotypes fits the Hardy-Weinberg equilibrium. Inheritance is autosomal codominant and fits the expectations of Mendelian inheritance. There is fetal synthesis, but no transplacental passage of plasminogen in either direction.

MeSH Terms
Adult Alleles Asians Blacks Female Gene Frequency Genes, Dominant Genetic Variation Humans Hydrogen-Ion Concentration Immunoelectrophoresis Infant, Newborn Isoelectric Focusing Male Maternal-Fetal Exchange Plasminogen/genetics,immunology Polymorphism, Genetic Pregnancy Whites
Chemicals
Plasminogen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Raum D
Marcus D
Alper C A
References (17)
17 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1980-09-00
Pages
681-9
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1686101
Subset
IM
Grants
NIAID NIH HHS · AI-14157 · United States
NIAID NIH HHS · AI-15033 · United States
NHLBI NIH HHS · HL-11414 · United States
External Links
PubMed source PMC Full Text View journal details
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