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PMID: 7152515 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

X-autosome translocations: cytogenetic characteristics and their consequences.

Human genetics ·Vol. 61 ·No. 4 ·1982-00-00 ·Pages 295-309

Mattei MG, Mattei JF, Ayme S, Giraud F

Abstract

To define the principal characteristics of X-autosome translocations, the authors present a study of 105 cases, five of which are personal observations. The autosomal pairs 15, 21, and 22 are affected by t(X-Aut) more often than would be expected. The distribution of breakpoints on the X chromosome does not differ significantly from the expected distribution. The analysis of different patterns of inactivation seems to confirm that the inactivation could occur at random, but would be followed by a cellular selection favoring the better genetic balance. An estimate of the incidence of t(X-Aut) is proposed, based upon the conclusions that only one chromosome is susceptible to translocation in meiosis in both males and females and that all affected men will be sterile, as will be 50% of women.

MeSH Terms
Chromosome Banding Chromosomes, Human/ultrastructure Dosage Compensation, Genetic Female Humans Infertility/genetics Male Meiosis Phenotype Sex Chromosomes/ultrastructure Translocation, Genetic X Chromosome/ultrastructure
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mattei M G
Mattei J F
Ayme S
Giraud F
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101 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00276593
Published
1982-00-00
Pages
295-309
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00276593 View journal details
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