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PMID: 7035334 Published · ppublish English Journal Article Review

Adjacent 2 meiotic disjunction. report of a case resulting from a familial 13q;15q balanced reciprocal translocation and review of the literature.

Human genetics ·Vol. 58 ·No. 4 ·1981-00-00 ·Pages 377-86

Duckett DP, Roberts SH

Abstract

An abnormal short-lived female infant with almost complete trisomy 13 (pter leads to q32 or 33) and partial monosomy 15 (pter leads to q14 or 15) resulting from an adjacent 2 meiotic disjunction of a paternal reciprocal translocation is described. Cases with monosomy of chromosome 15 material are reviewed. It appears likely that monosomy of an interstitial long arm segment, approximating to 15q21 leads to 24, imparts the lethality associated with the full monosomic condition. Adjacent 2 disjunction in man has been further characterised by reviewing the literature.

MeSH Terms
Abnormalities, Multiple/genetics Chromosomes, Human, 13-15/ultrastructure Female Humans Infant, Newborn Pedigree Phenotype Translocation, Genetic Trisomy
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Duckett D P
Roberts S H
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51 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00282819
Published
1981-00-00
Pages
377-86
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00282819 View journal details
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