Familial translocation t(10;21)(q22;q22).

Human genetics ·Vol. 50 ·No. 3 ·1979-09-00 ·Pages 253-8

Delicado A, Pajares IL, Vicente P, Hawkins F

Abstract

A family is described with a translocation t(10;21)(q22;q22) transmitted through three generations. This family was studied for the apparition of several miscarriages and two sisters with multiple malformations. Both children had a probably partial trisomy of chromosome 10 and a monosomy of chromosome 21 due to a maternal adjacent-2 meiotic segregation.

MeSH Terms

Abnormalities, Multiple/genetics Abortion, Habitual/genetics Chromosome Aberrations/genetics Chromosome Disorders Chromosomes, Human, 21-22 and Y Chromosomes, Human, 6-12 and X Female Humans Infant, Newborn Karyotyping Male Pedigree Pregnancy Translocation, Genetic Trisomy

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Delicado A

Pajares I L

Vicente P

Hawkins F

References (20)

20 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00399390

Published

1979-09-00

Pages

253-8

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00399390 View journal details

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