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PMID: 7001462 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of ornithine decarboxylase by renin-free nerve growth factor.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 8 ·1980-08-00 ·Pages 4607-9

Guroff G, Montgomery P, Tolson N, Lewis ME, End D

Abstract

Renin-free nerve growth factor causes the induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in superior cervical ganglia from neonatal rats but not in the brain of mature rats. Less pure preparations of nerve growth factor induce the enzyme in both brain and ganglia. The induction of ornithine decarboxylase in the central nervous system appears to be due to renin, not to nerve growth factor itself.

MeSH Terms
Angiotensin II/pharmacology Animals Brain/enzymology Carboxy-Lyases/biosynthesis Drinking Behavior/drug effects Enzyme Induction/drug effects Ganglia/enzymology Liver/enzymology Male Nerve Growth Factors/pharmacology Ornithine Decarboxylase/biosynthesis Rats Renin/pharmacology
Chemicals
Nerve Growth Factors Angiotensin II Renin Carboxy-Lyases Ornithine Decarboxylase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Guroff G
Montgomery P
Tolson N
Lewis M E
End D
References (31)
31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.8.4607
Published
1980-08-00
Pages
4607-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349893
Subset
IM
Grants
NICHD NIH HHS · F32-HD05905-01 · United States
External Links
PubMed source DOI: 10.1073/pnas.77.8.4607 PMC Full Text View journal details
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