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PMID: 200929 Published · ppublish English Journal Article

Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 10 ·1977-10-00 ·Pages 4681-4

MacDonnell PC, Nagaiah K, Lakshmanan J, Guroff G

Abstract

Nerve growth factor produces a rapid increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in superior cervical ganglia of young rats in vivo and in vitro. Maximum activity occurs 6-7 hr after the addition of nerve growth factor. The nerve growth factor-mediated increase in ornithine decarboxylase activity in vitro can be prevented by the addition of cycloheximide, actinomycin D, or antibody to nerve growth factor. A number of other agents were tested for their ability to increase ornithine decarboxylase were tested for their ability to increase ornithine decarboxylase activity in the ganglia; only nerve growth factor, and, to a slight extent, insulin were able to raise the activity of the enzyme. High concentrations of dibutyryl cyclic AMP (10 mM) were able to mimic the effect of nerve growth factor.

MeSH Terms
Animals Bucladesine/pharmacology Carboxy-Lyases/metabolism Dibutyryl Cyclic GMP/pharmacology Ganglia, Spinal/enzymology In Vitro Techniques Nerve Growth Factors/pharmacology Ornithine Decarboxylase/metabolism Phosphodiesterase Inhibitors/pharmacology Rats Stimulation, Chemical Time Factors
Chemicals
Nerve Growth Factors Phosphodiesterase Inhibitors Dibutyryl Cyclic GMP Bucladesine Carboxy-Lyases Ornithine Decarboxylase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
MacDonnell P C
Nagaiah K
Lakshmanan J
Guroff G
References (18)
18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.10.4681
Published
1977-10-00
Pages
4681-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432011
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.10.4681 PMC Full Text View journal details
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