The effect of nerve growth factor on cycle AMP levels in superior cerival ganglia of the rat.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 12 ·1975-12-00 ·Pages 4769-71

Nikodijevic B, Nikodijevic O, Yu MY, Pollard H, Guroff G

Abstract

Nerve growth factor (NGF) produces a several-fold increase in the cyclic AMP concentration in rat superior cervical ganglia in organ culture within 5 min. An increase can be seen with as little as 40 ng/ml of NGF. Oxidized NGF is without effect. The increase in the cAMP concentration produced by NGF is prevented by the addition of antiserum to NGF.

MeSH Terms

Animals Cyclic AMP/metabolism Ganglia, Spinal/drug effects,metabolism Male Mice Nerve Growth Factors/immunology,pharmacology Oxidation-Reduction Precipitin Tests Rats

Chemicals

Nerve Growth Factors Cyclic AMP

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Nikodijevic B

Nikodijevic O

Yu M Y

Pollard H

Guroff G

References (27)

27 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.12.4769

Published

1975-12-00

Pages

4769-71

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388812

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.12.4769 PMC Full Text View journal details

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The effect of nerve growth factor on cycle AMP levels in superior cerival ganglia of the rat.

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