Home LiteratureArticle Details
PMID: 16592486 Published · ppublish English Journal Article

Nerve growth factor increases activity of ornithine decarboxylase in rat brain.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 2 ·1978-02-00 ·Pages 1021-3

Lewis ME, Lakshmanan J, Nagaiah K, Macdonnell PC, Guroff G

Abstract

Intraventricular administration of nanogram quantities of nerve growth factor to adult rats results in a marked increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in the brain. The increase occurs in all major brain regions and the activity is maximal by 7.5 hr after administration. The enzyme response to nerve growth factor increases in magnitude during maturation; the relative increase in ornithine decarboxylase activity in adult animals is much greater than that in young. Neither insulin nor bovine growth hormone was able to increase ornithine decarboxylase activity to the same extent as did nerve growth factor. When brain was separated into neuronal- and glial-enriched fractions, induction of ornithine decarboxylase was found in both, but a greater increase was observed in the glial fraction.

Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lewis M E
Section on Intermediary Metabolism, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014.
Lakshmanan J
Nagaiah K
Macdonnell P C
Guroff G
References (24)
24 references, click to expand
  1. Control of adenylate cyclase from secretory vesicle membranes by beta-adrenergic agents and nerve growth factor.
    Proc Natl Acad Sci U S A. 1976 Mar;73(3):771-4 PMID: 3780
  2. Nerve growth factor and the activity of tyrosine hydroxylase in organ cultures of rat superior cervical ganglia.
    J Neurochem. 1977 Apr;28(4):835-42 PMID: 19562
  3. Studies on regulatory factors of ornithine decarboxylase activity during development of mouse mammary epithelium in vitro.
    J Biol Chem. 1976 Mar 25;251(6):1738-44 PMID: 176159
  4. Proposed model of major sequential biochemical events of a trophic response.
    Life Sci. 1976 Nov 1;19(9):1297-305 PMID: 186683
  5. Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats.
    Proc Natl Acad Sci U S A. 1977 Oct;74(10):4681-4 PMID: 200929
  6. Ornithine decarboxylase may function as an initiation factor for RNA polymerase I.
    Science. 1977 Feb 4;195(4277):505-6 PMID: 835013
  7. Subcellular localization of nerve growth factor receptors. Developmental correlations in chick embryo brain.
    J Biol Chem. 1976 Mar 10;251(5):1524-8 PMID: 943395
  8. Nerve growth factor and its mode of action.
    Exp Neurol. 1975 Sep;48(3 pt. 2):75-92 PMID: 1102324
  9. Subcellular localization of nerve growth factor receptors. Thirteen-day chick embryo brain.
    J Biol Chem. 1976 Mar 10;251(5):1516-23 PMID: 1254582
  10. Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo.
    J Pharm Pharmacol. 1973 Jun;25(6):437-40 PMID: 4146580
  11. Inhibition of the regenerative growth of central noradrenergic neurons by intracerebrally administered anti-NGF serum.
    Brain Res. 1974 Jul 5;74(1):1-18 PMID: 4152614
  12. Stimulation by insulin of ornithine decarboxylase activity in cultured mammary tissue.
    Biochim Biophys Acta. 1973 Oct 5;320(3):610-6 PMID: 4356535
  13. Growth and lactogenic hormone stimulation of ornithine decarboxylase in neonatal rat brain.
    Endocrinology. 1974 Sep;95(3):904-11 PMID: 4408225
  14. Properties and specificity of binding sites for 125I-nerve growth factor in embryonic heart and brain.
    J Biol Chem. 1974 Sep 25;249(18):5918-23 PMID: 4415337
  15. Nerve growth factor: enhanced recovery of feeding after hypothalamic damage.
    Science. 1973 May 4;180(4085):506-8 PMID: 4700605
  16. Stimulation of growth of new axonal sprouts from lesioned monoamine neurones in adult rat brain by nerve growth factor.
    Brain Res. 1973 Sep 28;60(1):161-76 PMID: 4744759
  17. Specific binding sites for 125I-nerve growth factor in peripheral tissues and brain.
    Biochem Biophys Res Commun. 1974 Apr 23;57(4):1096-103 PMID: 4830749
  18. Independence of protein synthesis and drug uptake in nerve cell bodies and glial cells isolated by a new technique.
    Nat New Biol. 1971 Apr 21;230(16):253-6 PMID: 4929986
  19. The nerve growth factor: purification as a 30,000-molecular-weight protein.
    Proc Natl Acad Sci U S A. 1969 Oct;64(2):787-94 PMID: 4982360
  20. Nerve growth factor and insulin.
    Science. 1972 May 5;176(4034):482-8 PMID: 5032347
  21. Ornithine decarboxylase activity in developing rat brain.
    J Neurochem. 1972 Jun;19(6):1471-81 PMID: 5035297
  22. Nerve growth factor: stimulation of regenerative growth of central noradrenergic neurons.
    Science. 1972 Mar 17;175(4027):1251-3 PMID: 5061245
  23. A sensitive radioimmunoassay for 7S nerve growth factor antigens in serum and tissues.
    J Neurochem. 1971 Dec;18(12):2355-62 PMID: 5135898
  24. Hormonal stimulation of hepatic ornithine decarboxylase.
    Biochem Biophys Res Commun. 1971 Apr 16;43(2):346-50 PMID: 5577448
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.2.1021
Published
1978-02-00
Pages
1021-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411392
External Links
PubMed source DOI: 10.1073/pnas.75.2.1021 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2