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PMID: 6801659 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mouse IgA heavy chain gene sequence: implications for evolution of immunoglobulin hinge axons.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 12 ·1981-12-00 ·Pages 7684-8

Tucker PW, Slightom JL, Blattner FR

Abstract

The complete nucleotide sequence of the gene and mRNA coding for the constant (C) region of the secreted form of the BALB/c mouse IgA immunoglobulin alpha heavy (H) chain has been determined. As in other immunoglobulins, the three C region domains of the alpha protein, C alpha 1, C alpha 2, and C alpha 3 are coded in separate exons. However, the hinge region of C alpha is not coded on a separate exon as it is in other hinge-containing immunoglobulins. Instead, the alpha hinge is coded as a 5' extension of the C alpha 2 exon, and we suggest that it may have evolved by duplication leading to incorporation of an acceptor RNA splice site into the coding portion of the C alpha 2 exon. Extensions of this concept could provide an explanation for duplications in the human alpha 1 chain.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Codon Genes Immunoglobulin Constant Regions/genetics Immunoglobulin Heavy Chains/genetics Immunoglobulin alpha-Chains/genetics Immunoglobulins/genetics Mice RNA Splicing RNA, Messenger/genetics
Chemicals
Codon Immunoglobulin Constant Regions Immunoglobulin Heavy Chains Immunoglobulin alpha-Chains Immunoglobulins RNA, Messenger
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tucker P W
Slightom J L
Blattner F R
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28 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.12.7684
Published
1981-12-00
Pages
7684-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349334
Subset
IM
Grants
NIAID NIH HHS · AI18016 · United States
NIGMS NIH HHS · GM21812 · United States
Databases
GENBANK
J00475
External Links
PubMed source DOI: 10.1073/pnas.78.12.7684 PMC Full Text View journal details
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