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PMID: 416441 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 2 ·1978-02-00 ·Pages 966-9

Toraño A, Putnam FW

Abstract

The complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m(2) allotype has been determined and is compared to the sequence of the alpha 1 chain of the human IgA1 subclass. The characteristic differences between the alpha 1 and alpha 2 chains are greatest in the hinge region and in the location and number of the oligosaccharides. Apart from the duplication in the hinge region of alpha 1 and the deletion in alpha 2, there are 23 amino acid exchanges in the constant (C) regions of the two chains. Accepted mutations are related to the surface accessibility of the residues and the proximity of carbohydrate. The results indicate that human IgA and IgG subclasses arose late in evolution and reflect similar mutationa pressures.

MeSH Terms
Amino Acid Sequence Immunoglobulin A Immunoglobulin Allotypes Immunoglobulin Heavy Chains Immunoglobulin Variable Region Oligosaccharides/analysis
Chemicals
Immunoglobulin A Immunoglobulin Allotypes Immunoglobulin Heavy Chains Immunoglobulin Variable Region Oligosaccharides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Toraño A
Putnam F W
References (18)
18 references, click to expand
  1. Location and structural significance of the oligosaccharides in human Ig-A1 and IgA2 immunoglobulins.
    Proc Natl Acad Sci U S A. 1977 Jun;74(6):2301-5 PMID: 407576
  2. On the location of palindromes in immunoglobulin genes.
    Proc Natl Acad Sci U S A. 1977 Jun;74(6):2526-30 PMID: 267946
  3. Activation of the classical complement pathway by Fc fragment of human IgA.
    J Immunol. 1977 Feb;118(2):723-5 PMID: 839077
  4. Crystallographic structure studies of an IgG molecule and an Fc fragment.
    Nature. 1976 Dec 2;264(5585):415-20 PMID: 1004567
  5. The complete sequence of the murine monoclonal immunoglobulin MOPC 173 (IgG2a): genetic implications.
    Ann Immunol (Paris). 1976 Sep-Oct;127(5):607-31 PMID: 984731
  6. Neisseria gonorrhoeae and neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A.
    Science. 1975 Dec 12;190(4219):1103-5 PMID: 810892
  7. Conformational parameters for amino acids in helical, beta-sheet, and random coil regions calculated from proteins.
    Biochemistry. 1974 Jan 15;13(2):211-22 PMID: 4358939
  8. Site of J chain attachment to human polymeric IgA.
    Proc Natl Acad Sci U S A. 1974 Feb;71(2):544-8 PMID: 4131279
  9. Isolation, properties, and structure of human IgA myeloma globulins.
    Adv Exp Med Biol. 1974;45(0):177-89 PMID: 4213208
  10. Characterization of a disulfide bridge linking the J chain to the alpha chain of polymeric immunoglobulin A.
    Biochem Biophys Res Commun. 1973 Dec 19;55(4):1291-7 PMID: 4203905
  11. The first isoallotype of human IgA proteins. An antigenic determinant occurring as allotype in the IgA2 subclass and as isotype in the IgA1 subclass.
    Scand J Immunol. 1976;5(1-2):161-4 PMID: 57639
  12. Structure of immunoglobulin A. II. Sequence around the hinge region and labile disulfide bonds of an immunoglobulin A2 myeloma protein.
    Biochemistry. 1972 Oct 10;11(21):3971-5 PMID: 4562586
  13. Complete covalent structure of a human IgA1 immunoglobulin.
    Science. 1976 Sep 10;193(4257):1017-20 PMID: 821146
  14. [The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule (author's transl)].
    Hoppe Seylers Z Physiol Chem. 1975 Aug;356(8):1337-42 PMID: 809331
  15. Structure and function of the constant regions of immunoglobulins.
    Q Rev Biophys. 1976 May;9(2):135-80 PMID: 785525
  16. Partial amino acid sequence of an IgA2 human immunoglobulin heavy chain.
    Biochim Biophys Acta. 1975 Feb 27;379(2):627-37 PMID: 804325
  17. Structure, function, and evolutionary relationships of Fc domains of human immunoglobulins A, G, M, and E.
    Science. 1976 Jan 30;191(4225):390-2 PMID: 1246619
  18. Three variable-gene pools common to IgM, IgG and IgA immunoglobulins.
    Nature. 1970 Sep 26;227(5265):1318-20 PMID: 5465942
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.2.966
Published
1978-02-00
Pages
966-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411380
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.2.966 PMC Full Text View journal details
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