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PMID: 6801081 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Pre-B cells; normal and abnormal development.

Journal of clinical immunology ·Vol. 1 ·No. 2 ·1981-04-00 ·Pages 81-9

Cooper MD

Abstract

The immediate precursors of B lymphocytes have been recently identified in fetal liver and in bone marrow. Immunoglobulin genes, first of the heavy-chain gene family and later from one of the light-chain gene families, are selected and undergo functional rearrangements on one of each chromosomal pair during this stage of differentiation. Thus clonal diversity is generated among cycling pre-B cells that lack the surface antibody expression which characterizes their B-cell progeny. While the number of discriminating markers for pre-B cells is still limited, examination of bone marrow pre-B cells containing cytoplasmic mu chains but lacking surface immunoglobulin has already revealed an informative spectrum of early differentiation defects in antibody deficiency diseases and malignancies of B lineage.

MeSH Terms
Animals Antigens, Ly/immunology B-Lymphocytes/cytology,pathology Birds Bone Marrow Cells Cell Differentiation Cell Transformation, Neoplastic/pathology Female Fetus/cytology Humans Immunoglobulin Heavy Chains/genetics Immunoglobulin Light Chains/genetics Immunologic Deficiency Syndromes/immunology,pathology Kinetics Leukemia, Experimental/immunology,pathology Leukemia, Lymphoid/immunology,pathology Liver/cytology Mice Mice, Inbred Strains Pregnancy Rabbits Receptors, Antigen, B-Cell/immunology
Chemicals
Antigens, Ly Immunoglobulin Heavy Chains Immunoglobulin Light Chains Receptors, Antigen, B-Cell
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Cooper M D
References (61)
61 references, click to expand
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00915383
Published
1981-04-00
Pages
81-9
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
Grants
NCRR NIH HHS · 5M01-RR32 · United States
NCI NIH HHS · CA 13148 · United States
NCI NIH HHS · CA 16673 · United States
External Links
PubMed source DOI: 10.1007/BF00915383 View journal details
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