Pre-B and B cells in children on leukaemia remission maintenance treatment.

Clinical and experimental immunology ·Vol. 37 ·No. 2 ·1979-08-00 ·Pages 259-66

Paolucci P, Hayward AR, Rapson NT

Abstract

The percentage of pre-B cells, mature B cells and IgM plasma cells were reduced in the marrow of children receiving continuous cytotoxic drug treatment to maintain leukaemia remission, compared with children receiving intermittent drug treatment in the UKALL V trial or untreated controls. When treatment was ended, the proportion of marrow pre-B cells rose above that of the controls and remained elevated for more than 6 months. These observations define more precisely the cellular basis of suppression of antibody immunity by cytotoxic drugs. They also suggest the existence of a complex feedback control of pre-B cell numbers and B cell differentiation during recovery.

MeSH Terms

Adolescent B-Lymphocytes/immunology Bone Marrow/pathology Cell Differentiation Child Child, Preschool Humans Immunoglobulin G/analysis Immunoglobulin M/analysis Leukemia, Lymphoid/drug therapy,immunology,pathology Plasma Cells/immunology Receptors, Antigen, B-Cell/analysis

Chemicals

Immunoglobulin G Immunoglobulin M Receptors, Antigen, B-Cell

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Paolucci P

Hayward A R

Rapson N T

References (13)

13 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1979-08-00

Pages

259-66

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1537816

Subset

External Links

PubMed source PMC Full Text View journal details

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Pre-B and B cells in children on leukaemia remission maintenance treatment.

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