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PMID: 6969730 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A unique cell surface antigen identifying lymphoid malignancies of B cell origin.

The Journal of clinical investigation ·Vol. 67 ·No. 1 ·1981-01-00 ·Pages 134-40

Nadler LM, Ritz J, Hardy R, Pesando JM, Schlossman SF, Stashenko P

Abstract

A monoclonal antibody (anti-B1) specific for a unique B cell surface differentiation antigen was used to characterize the malignant cells from patients with leukemias or lymphomas. All tumor cells from patients with lymphomas or chronic lymphocytic leukemias, bearing either monoclonal kappa lambda light chain, expressed the B1 antigen. In contrast, tumor cells from T cell leukemias and lymphomas or acute myeloblastic leukemia were unreactive. Approximately 50% of acute lymphoblastic leukemias (ALL) of non-T origin and 50% of chronic myelocytic leukemia in blast crisis were also anti-B1 reactive. moreover, 21 of 28 patients with the common ALL antigen (CALLA) positive form of ALL were anti-B1 positive, whereas 0 of 13 patients with CALLA negative ALL were reactive. These observations demonstrate that an antigen present on normal B cells is expressed on the vast majority of B cell lymphomas and on approximately 75% of CALLA positive ALL, suggesting that these tumors may share a common B cell lineage.

MeSH Terms
Antibodies Antigens, Neoplasm/analysis Antigens, Surface/analysis B-Lymphocytes/immunology Clone Cells Humans Leukemia/immunology Leukemia, Lymphoid/immunology Leukemia, Myeloid/immunology Lymphoma/immunology
Chemicals
Antibodies Antigens, Neoplasm Antigens, Surface
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Nadler L M
Ritz J
Hardy R
Pesando J M
Schlossman S F
Stashenko P
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI110005
Published
1981-01-00
Pages
134-40
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC371580
Subset
IM
Grants
NIAID NIH HHS · AI 12069 · United States
NCI NIH HHS · CA 06516 · United States
NCI NIH HHS · CA 19589 · United States
External Links
PubMed source DOI: 10.1172/JCI110005 PMC Full Text View journal details
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