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PMID: 6789351 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Amphetamine withdrawal: effects on threshold of intracranial reinforcement.

Psychopharmacology ·Vol. 73 ·No. 4 ·1981-00-00 ·Pages 318-22

Cassens G, Actor C, Kling M, Schildkraut JJ

Abstract

In order to determine whether alterations in sensitivity to rewarding stimuli accompany the biochemical and behavioral changes induced by chronic amphetamine treatment and withdrawal, we explored the effects of chronic administration and withdrawal of d-amphetamine on thresholds of intracranial reinforcement in the rat. Rats were injected with d-amphetamine sulfate according to a chronic, escalating dose schedule. Marked decreases in threshold of intracranial reinforcement were observed immediately (0--1 h) following the last injection of d-amphetamine. In contrast, all animals showed marked increases in thresholds of intracranial reinforcement 24-48 h after the last injection of d-amphetamine. These findings were discussed in relation to amphetamine-induced and naturally occurring depressions in man.

MeSH Terms
Animals Behavior, Animal/drug effects Depression/etiology Dextroamphetamine/pharmacology Disease Models, Animal Humans Male Rats Reinforcement, Psychology Self Stimulation/drug effects Sensory Thresholds/drug effects Substance Withdrawal Syndrome/physiopathology
Chemicals
Dextroamphetamine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cassens G
Actor C
Kling M
Schildkraut J J
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30 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00426458
Published
1981-00-00
Pages
318-22
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
Grants
NIDA NIH HHS · DA-01460 · United States
NIMH NIH HHS · MH-15413 · United States
External Links
PubMed source DOI: 10.1007/BF00426458 View journal details
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