Response sensitization and depression following long-term amphetamine treatment in a self-stimulation paradigm.

Psychopharmacology ·Vol. 68 ·No. 1 ·1980-00-00 ·Pages 73-6

Kokkinidis L, Zacharko RM

Abstract

The effects of long-term amphetamine treatment were evaluated on responding supported by self-stimulation of the substantia nigra. Rats repeatedly treated with d-amphetamine, and tested with a low dose of the drug that ordinarily has no behavioral effect, showed higher response rates than animals repeatedly treated with saline and tested with the same dose of amphetamine. In contrast, a depression in responding was observed among animals that received long-term amphetamine administration and were tested with saline. The effects of long-term amphetamine treatment on self-stimulation could not be explained by the intrusion of drug-induced competitive behaviors such as locomotor activity and stereotypy. The results were attributed to changes in dopamine neurotransmission following prolonged exposure to amphetamine and were also discussed in terms of an animal model for 'amphetamine psychosis' and 'postamphetamine depression' in man.

MeSH Terms

Amphetamine/pharmacology Animals Dextroamphetamine/pharmacology Dose-Response Relationship, Drug Electric Stimulation Male Rats Self Stimulation/drug effects Substantia Nigra/physiology Time Factors

Chemicals

Amphetamine Dextroamphetamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kokkinidis L

Zacharko R M

References (14)

14 references, click to expand

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Article Info

Journal

Psychopharmacology

Abbr.

Psychopharmacology (Berl)

ISSN

0033-3158

DOI

10.1007/BF00426653

Published

1980-00-00

Pages

73-6

Language

English

Region

Germany

NLM ID

7608025

Subset

External Links

PubMed source DOI: 10.1007/BF00426653 View journal details

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Response sensitization and depression following long-term amphetamine treatment in a self-stimulation paradigm.

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