Involvement of norepinephrine in startle arousal after acute and chronic d-amphetamine administration.

Psychopharmacology ·Vol. 59 ·No. 3 ·1978-12-08 ·Pages 285-92

Kokkinidis L, Anisman H

Abstract

Treatment with d-amphetamine produced a dose-dependent increase in startle amplitude in response to a buzzer. This increase appeared to be a reflection of a sensitization effect, i.e., enhanced responsivity as a function of repeated stimulus presentations. Treatment with alpha-methyl-p-tyrosine, which reduced whole brain concentrations of dopamine (DA) and norepinephrine (NE), or treatment with FLA-63, which reduced only NE, antagonized the effects of d-amphetamine on the startle reflex, suggesting a role of NE in this behavior. Startle amplitude was also reduced following chronic d-amphetamine treatment. The effect of d-amphetamine on startle was found to be independent of changes in drug-induced locomotor excitation. The data of the present investigation, together with earlier reports, suggests that tolerance occurs to those behaviors that involve a noradrenergic component.

MeSH Terms

Animals Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide/pharmacology Dextroamphetamine/pharmacology Male Methyltyrosines/pharmacology Mice Norepinephrine/physiology Reflex, Startle/drug effects Time Factors

Chemicals

Methyltyrosines Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide Dextroamphetamine Norepinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kokkinidis L

Anisman H

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22 references, click to expand

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Article Info

Journal

Psychopharmacology

Abbr.

Psychopharmacology (Berl)

ISSN

0033-3158

DOI

10.1007/BF00426636

Published

1978-12-08

Pages

285-92

Language

English

Region

Germany

NLM ID

7608025

Subset

External Links

PubMed source DOI: 10.1007/BF00426636 View journal details

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Involvement of norepinephrine in startle arousal after acute and chronic d-amphetamine administration.

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