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PMID: 6733017 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.

British journal of cancer ·Vol. 49 ·No. 6 ·1984-06-00 ·Pages 681-8

Spandidos DA, Kerr IB

Abstract

Study of expression of ras-related oncogenes in human premalignant polyps and malignant tumours of the colorectum, as well as in normal colorectal mucosa, shows a significant elevation in the premalignant and malignant tissues as compared to their respective colorectal mucosa. These results suggest that activation of the ras oncogene family occurs in the development of colorectal tumours and that elevated expression at a premalignant stage may well be critical in the process of carcinogenesis but not in itself sufficient.

MeSH Terms
Cell Line Colon/analysis Colonic Neoplasms/analysis,genetics Gene Expression Regulation Humans Intestinal Mucosa/analysis Nucleic Acid Hybridization Oncogenes Precancerous Conditions/analysis,genetics RNA, Neoplasm/analysis Rectal Neoplasms/analysis,genetics Rectum/analysis
Chemicals
RNA, Neoplasm
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Spandidos D A
Kerr I B
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34 references, click to expand
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1984.108
Published
1984-06-00
Pages
681-8
Language
English
Region
England
NLM ID
0370635
PMCID
PMC1976851
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1984.108 PMC Full Text View journal details
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