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PMID: 6723846 Published · ppublish English Journal Article

Metabolic activity of intracerebellar nuclei in the rat: effects of inferior olive inactivation.

Experimental brain research ·Vol. 54 ·No. 2 ·1984-00-00 ·Pages 259-65

Batini C, Benedetti F, Buisseret-Delmas C, Montarolo PG, Strata P

Abstract

Metabolic activity of the intracerebellar nuclei during cryoinactivation of the inferior olive was studied in the anaesthetized rat by using the 14C-2-deoxyglucose method. Single unit recording of Purkinje cells was simultaneously monitored in the cerebellar cortex. Local inactivation in the inferior olive resulted in regional suppression of complex spike discharges in the cerebellar cortex. An increased metabolic activity was observed in the cerebellar nuclei contralateral to the cryoinactivation site correlating the somatotopically arranged olivo-cerebello-nuclear circuit. This increase was shown to be due specifically to inactivation of the inferior olive, since it was not obtained in a rat in which the inferior olive was previously destroyed by neurotoxic doses of 3-acetylpyridine. The results are interpreted as being due to an increased presynaptic activity of the terminals of the Purkinje cells which fire simple spikes at high rates after climbing fibre deafferentation.

MeSH Terms
Animals Autoradiography Cerebellar Nuclei/metabolism Cold Temperature Electrophysiology Olivary Nucleus/physiology Rats
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Batini C
Benedetti F
Buisseret-Delmas C
Montarolo P G
Strata P
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00236225
Published
1984-00-00
Pages
259-65
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00236225 View journal details
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