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PMID: 6455300 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Are the climbing fibres essential for the Purkinje cell inhibitory action?

Experimental brain research ·Vol. 42 ·No. 2 ·1981-00-00 ·Pages 215-8

Montarolo PG, Raschi F, Strata P

Abstract

Following an almost total chemical lesion of the inferior olive, the inhibitory control of the cerebellar Purkinje cells upon their target neurones, mainly in Deiters nucleus, remains practically unchanged. This result is at variance with some recent findings having important implications in the cerebellar theories of motor learning.

MeSH Terms
Animals Cerebellum/physiology Harmaline/pharmacology Neurons/drug effects,physiology Niacinamide/pharmacology Olivary Nucleus/physiology Purkinje Cells/drug effects,physiology Pyridines/pharmacology Rats
Chemicals
Pyridines 3-acetylpyridine Niacinamide Harmaline
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Montarolo P G
Raschi F
Strata P
References (9)
9 references, click to expand
  1. Destruction of inferior olive induces rapid depression in synaptic action of cerebellar Purkinje cells.
    Nature. 1979 Feb 15;277(5697):568-9 PMID: 216922
  2. Diminution and reversal of eye movements induced by local stimulation of rabbit cerebellar flocculus after partial destruction of the inferior olive.
    Exp Brain Res. 1978 Sep 15;33(1):139-41 PMID: 699997
  3. On the inferior olive of the albino rat.
    J Comp Neurol. 1970 Nov;140(3):255-60 PMID: 5476885
  4. The mammalian cerebellum and its contribution to movement control.
    Int Rev Physiol. 1978;17:239-94 PMID: 359498
  5. Electrophysiological analysis of the vestibulospinal reflex pathway of rabbit. I. Classification of tract cells.
    Exp Brain Res. 1973 Jul 30;17(5):477-96 PMID: 4741250
  6. Inferior olive: its role in motor learing.
    Science. 1975 Dec 19;190(4220):1230-1 PMID: 128123
  7. Reduction of the cerebellar stimulus effect on rat Deiters neurons after chemical destruction of the inferior olive.
    Exp Brain Res. 1978 Sep 15;33(1):143-5 PMID: 699998
  8. A theory of cerebellar cortex.
    J Physiol. 1969 Jun;202(2):437-70 PMID: 5784296
  9. Olivocerebellar projections in the cat studied by means of anterograde axonal transport of labelled amino acids as tracers.
    Neuroscience. 1979;4(11):1615-33 PMID: 92769
Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00236909
Published
1981-00-00
Pages
215-8
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00236909 View journal details
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