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PMID: 6497830 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A structural gene (Hdc-s) for mouse kidney histidine decarboxylase.

Biochemical genetics ·Vol. 22 ·No. 7-8 ·1984-08-00 ·Pages 645-56

Martin SA, Bulfield G

Abstract

The concentration of mouse kidney histidine decarboxylase (HDC) is modulated by estrogen, testosterone, and thyroxine in a tissue-specific manner. Variation in HDC levels between strains of mice can be used to investigate the genetic regulation of enzyme structure, tissue specific expression, and induction and repression by hormones. Variation in the structure of HDC between different inbred strains of mice affecting its Km for the cofactor pyridoxal-5'-phosphate (PLP) and its heat stability has been discovered. The alternative phenotypes are additively inherited in crosses and the heat stability difference is due to alleles of a single structural gene, Hdc-s, which segregate among the BXD and BXH recombinant inbred strains. The allele Hdc-sb determines the heat-stable phenotype (C57BL substrains), and the allele Hdc-sd the heat-labile phenotype (DBA/2 and C3H/He strains). The alleles of the structural gene cosegregate with alleles of a regulatory gene previously named Hdc (determining kidney enzyme concentration); there were no recombinants among 38 RI strains. Therefore the two loci are less than 0.685 cM apart and comprise part of the HDC gene complex, [Hdc], on chromosome 2 of the mouse.

MeSH Terms

Animals Carboxy-Lyases/genetics Crosses, Genetic Drug Stability Female Genes Histidine Decarboxylase/genetics,metabolism Kidney/enzymology Male Mice Mice, Inbred Strains Phenotype Pyridoxal Phosphate/pharmacology Sex Factors Species Specificity Terminology as Topic

Chemicals

Pyridoxal Phosphate Carboxy-Lyases Histidine Decarboxylase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Martin S A

Bulfield G

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Article Info

Journal

Biochemical genetics

Abbr.

Biochem Genet

ISSN

0006-2928

DOI

10.1007/BF00485850

Published

1984-08-00

Pages

645-56

Language

English

Region

United States

NLM ID

0126611

Subset

External Links

PubMed source DOI: 10.1007/BF00485850 View journal details

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A structural gene (Hdc-s) for mouse kidney histidine decarboxylase.

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