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PMID: 849251 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver.

Biochemical genetics ·Vol. 15 ·No. 1-2 ·1977-02-00 ·Pages 31-46

Dizik M, Elliott RW

Abstract

Organ-specific electrophoretic heterogeneity of lysosomal alpha-mannosidase has been observed within individual strains of inbred mice. Polymorphism between C57BL/6J and CBA/J for liver lysosomal alpha-mannosidase is determined by a single genetic locus on chromosome 5 and appears to be the result of differences in sialylation of the lysosomal enzyme. Two different patterns of expression of development of the liver electrophoretic forms have been observed.

MeSH Terms
Animals Brain/enzymology Chromosome Mapping Disaccharidases/metabolism Electrophoresis, Cellulose Acetate Genes Genetic Linkage Liver/enzymology Lung/enzymology Lysosomes/enzymology Mannosidases/metabolism Mice/metabolism Mice, Inbred Strains Neuraminidase/metabolism Organ Specificity Polymorphism, Genetic Spleen/enzymology
Chemicals
Disaccharidases Mannosidases Neuraminidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dizik M
Elliott R W
References (28)
28 references, click to expand
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Article Info
Journal
Biochemical genetics
Abbr.
Biochem Genet
ISSN
0006-2928
DOI
10.1007/BF00484546
Published
1977-02-00
Pages
31-46
Language
English
Region
United States
NLM ID
0126611
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00484546 View journal details
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