Abstract
The mouse mutants testicular feminization and sex reversal have been used to investigate hormone-mediated induction and repression of enzymes. Tfm/Y animals were already known to be androgen insensitive, rendering the androgen-inducible enzymes ADH and beta-glucuronidase noninducible because of an inherited deficiency of a cytosol androgen-receptor complex. The animals display female secondary sexual characteristics. Sxr/+,XX animals display male primary and secondary sexual characteristics with small testes. We demonstrate (1) that the Tfm mutation is pleiotropic, preventing repression of an androgen-repressible enzyme (ornithine aminotransferase) as well as induction of androgen-inducible enzymes, (2) that an estrogen-inducible enzyme (histidine decarboxylase) is not affected by the Tfm mutation, and (3) that Sxr/+,XX animals produce enough androgen for malelike activities of androgen-sensitive enzymes. It was also discovered that histidine decarboxylase repressed by androgen in normal animals, rather than being unaffected by it in Tfm/Y animals, is in fact induced. This unexpected phenomenon is discussed and an explanation is suggested for it.
MeSH Terms
Alcohol Oxidoreductases/metabolism
Androgen-Insensitivity Syndrome/enzymology
Animals
Dihydrotestosterone/pharmacology
Disorders of Sex Development
Enzyme Induction/drug effects
Enzyme Repression/drug effects
Estradiol/pharmacology
Female
Genotype
Glucuronidase/metabolism
Hexokinase/metabolism
Histidine Ammonia-Lyase/metabolism
Kidney/enzymology
Liver/enzymology
Male
Mice
Ornithine-Oxo-Acid Transaminase/metabolism
Phenotype
Urocanate Hydratase/metabolism
Chemicals
Dihydrotestosterone
Estradiol
Alcohol Oxidoreductases
Ornithine-Oxo-Acid Transaminase
Hexokinase
Glucuronidase
Urocanate Hydratase
Histidine Ammonia-Lyase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bulfield G
Nahum A
References (20)
20 references, click to expand
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