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PMID: 6387623 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Structure and organization of two linked ribosomal protein genes in yeast.

Nucleic acids research ·Vol. 12 ·No. 19 ·1984-10-11 ·Pages 7345-58

Molenaar CM, Woudt LP, Jansen AE, Mager WH, Planta RJ, Donovan DM, Pearson NJ

Abstract

The genes encoding yeast ribosomal proteins rp28 and S16A are linked and occur duplicated in the yeast genome. In both gene pairs the genes are approximately 600 bp apart and are both transcribed in the same direction. Both ribosomal protein genes resemble other ribosomal protein genes studied so far in many structural aspects. The genes are interrupted by an intron near the 5'-end of their coding sequence. In addition the flanking regions contain several conserved sequence elements, which may function in transcription initiation and termination. In agreement with findings concerning other cloned yeast ribosomal protein genes, upstream homology blocks occur that may be involved in coordinate control of ribosomal protein gene transcription. The complete pattern of conserved and diverged sequences between the two duplicate gene pairs is presented.

MeSH Terms
Amino Acid Sequence Base Sequence Genes Genes, Fungal Genetic Linkage RNA, Messenger/genetics Ribosomal Proteins/genetics Saccharomyces cerevisiae/genetics
Chemicals
RNA, Messenger Ribosomal Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Molenaar C M
Woudt L P
Jansen A E
Mager W H
Planta R J
Donovan D M
Pearson N J
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34 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.19.7345
Published
1984-10-11
Pages
7345-58
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320166
Subset
IM
Grants
NIGMS NIH HHS · GM 25532 · United States
NIGMS NIH HHS · GM 31812 · United States
Databases
GENBANK
X01099, X01100, X02635
External Links
PubMed source DOI: 10.1093/nar/12.19.7345 PMC Full Text View journal details
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