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PMID: 6322113 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats.

Nucleic acids research ·Vol. 12 ·No. 3 ·1984-02-10 ·Pages 1641-55

Schimenti JC, Duncan CH

Abstract

Bovine fetal and adult globin genes were cloned and subjected to DNA sequence analysis. Both of these genes contained insertions of Alu-type repetitive DNA within their introns. Comparison of cow and goat beta-type globin genes indicates that intragenic DNA insertions played a role in their evolution. These data support the theory that Alu-type repeats maintain genetic diversity by inhibiting gene conversion.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Cattle Cloning, Molecular DNA Transposable Elements Fetus Genes Globins/genetics Goats Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Species Specificity
Chemicals
DNA Transposable Elements Globins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schimenti J C
Duncan C H
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65 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.3.1641
Published
1984-02-10
Pages
1641-55
Language
English
Region
England
NLM ID
0411011
PMCID
PMC318605
Subset
IM
Grants
NHLBI NIH HHS · HL15996-11 · United States
Databases
GENBANK
X00354, X00376
External Links
PubMed source DOI: 10.1093/nar/12.3.1641 PMC Full Text View journal details
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