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PMID: 6318187 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The efficacy of agonists at the frog neuromuscular junction studied with single channel recording.

Pflugers Archiv : European journal of physiology ·Vol. 399 ·No. 3 ·1983-11-00 ·Pages 246-8

Ogden DC, Colquhoun D

Abstract

The efficacy of acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction was estimated by single channel recording. The probability of channel opening at high concentration was found to be greater than 0.9 for each, thus showing (a) that their efficacy is high and (b) that the opening rate for the fully-liganded channel is higher than previously thought.

MeSH Terms
Acetylcholine/pharmacology Animals Carbachol/pharmacology Choline/analogs & derivatives,pharmacology Electrophysiology Ion Channels/physiology Neuromuscular Junction/drug effects,physiology Rana temporaria
Chemicals
Ion Channels subecholine Carbachol Choline Acetylcholine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ogden D C
Colquhoun D
References (9)
9 references, click to expand
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    Nature. 1980 Jul 3;286(5768):71-3 PMID: 6248795
  5. Interaction at end-plate receptors between different choline derivatives.
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  7. Kinetic parameters for acetylcholine interaction in intact neuromuscular junction.
    Proc Natl Acad Sci U S A. 1981 Nov;78(11):7200-4 PMID: 6947281
  8. Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions.
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00656725
Published
1983-11-00
Pages
246-8
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00656725 View journal details
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