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PMID: 6312450 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Structural similarities between viroids and transposable genetic elements.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 20 ·1983-10-00 ·Pages 6234-8

Kiefer MC, Owens RA, Diener TO

Abstract

The primary structures of the tomato planta macho and tomato apical stunt viroids have been determined, and probable secondary structures are proposed. Both viroids can assume the rodlike conformation with extensive base-pairing characteristic of all known viroids. Sequence homologies between the two viroids (75%) and with members of the potato spindle tuber viroid group (73-83%) indicate that they both belong to this group. Comparative sequence analysis of all members of the group reveals striking similarities with the ends of transposable genetic elements. These similarities, the presence of inverted repeats often ending with the dinucleotides U-G and C-A, and flanking imperfect direct repeats suggest that viroids may have originated from transposable elements or retroviral proviruses by deletion of interior portions of the viral (or element) DNA.

MeSH Terms
Base Sequence Biological Evolution DNA Transposable Elements Genes Nucleic Acid Conformation Protein Biosynthesis Retroviridae/genetics Viral Proteins/genetics Viroids/genetics
Chemicals
DNA Transposable Elements Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kiefer M C
Owens R A
Diener T O
References (30)
30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.20.6234
Published
1983-10-00
Pages
6234-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC394270
Subset
IM
Databases
GENBANK
K00817, K00818
External Links
PubMed source DOI: 10.1073/pnas.80.20.6234 PMC Full Text View journal details
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