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PMID: 6298460 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Effects of tunicamycin on rotavirus morphogenesis and infectivity.

Journal of virology ·Vol. 46 ·No. 1 ·1983-04-00 ·Pages 270-4

Petrie BL, Estes MK, Graham DY

Abstract

The functions of the two rotavirus glycoproteins were investigated by using tunicamycin and a variant of SA11 rotavirus having nonglycosylated VP7. Results showed that glycosylation of VP7 is not required for normal viral morphogenesis and infectivity and suggested that the nonstructural glycoprotein is involved in assembly of the outer capsid.

MeSH Terms

Glucosamine/analogs & derivatives Microscopy, Electron Rotavirus/growth & development,pathogenicity Tunicamycin/pharmacology Viral Envelope Proteins Viral Proteins/antagonists & inhibitors Virus Replication/drug effects

Chemicals

Viral Envelope Proteins Viral Proteins Tunicamycin Glucosamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Petrie B L

Estes M K

Graham D Y

References (32)

32 references, click to expand

The polypeptides of adenovirus. VI. Early and late glycopolypeptides.
Virology. 1974 Apr;58(2):345-61 PMID: 4856570
Infantile enteritis viruses: morphogenesis and morphology.
J Virol. 1975 Oct;16(4):937-43 PMID: 1165598
Evidence for a glycoprotein in reovirus.
Virology. 1976 Jul 15;72(2):308-21 PMID: 948864
Suppression of glycoprotein formation of Semliki Forest, influenza, and avian sarcoma virus by tunicamycin.
J Virol. 1976 Sep;19(3):782-91 PMID: 184299
Tunicamycin inhibits glycosylation and multiplication of Sindbis and vesicular stomatitis viruses.
J Virol. 1977 Jan;21(1):375-85 PMID: 189071
Further biochemical characterization, including the detection of surface glycoproteins, of human, calf, and simian rotaviruses.
J Virol. 1977 Oct;24(1):91-8 PMID: 198589
Effects of glucosamine, 2-deoxyglucose, and tunicamycin on glycosylation, sulfation, and assembly of influenza viral proteins.
Virology. 1978 Feb;84(2):303-19 PMID: 622804
Calf rotavirus: detection of outer capsid glycoproteins by lectins.
FEBS Lett. 1978 Mar 1;87(1):26-30 PMID: 204517
Glycosylation is not necessary for membrane insertion and cleavage of Semliki Forest virus membrane proteins.
Nature. 1978 Aug 3;274(5670):487-90 PMID: 672976
Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate Glc-NAc-1-phosphate transferase.
Biochemistry. 1979 May 29;18(11):2186-92 PMID: 444447
Ultrastructural study of rotavirus replication in cultured cells.
J Gen Virol. 1980 Jan;46(1):75-85 PMID: 6243348
In vitro transcription and translation of simian rotavirus SA11 gene products.
J Virol. 1980 Mar;33(3):1111-21 PMID: 6245262
The effect of glycosylation inhibitors on the maturation and intracellular polypeptide synthesis induced by snowshoe hare bunyavirus.
Virology. 1980 May;103(1):235-40 PMID: 7368577
Effect of tunicamycin on herpes simplex virus glycoproteins and infectious virus production.
J Virol. 1980 Apr;34(1):142-53 PMID: 6246250
The role of viral glycoproteins in adsorption, penetration, and pathogenicity of viruses.
Rev Infect Dis. 1980 Jan-Feb;2(1):40-61 PMID: 6994202
Antiviral activity of tunicamycin on herpes simplex virus.
Antimicrob Agents Chemother. 1980 Jun;17(6):1014-22 PMID: 6250466
The budding mechanisms of enveloped animal viruses.
J Gen Virol. 1980 Sep;50(1):1-21 PMID: 6255080
The replication of measles virus in the presence of tunicamycin.
Virology. 1981 Jan 30;108(2):391-404 PMID: 7467126
Electron microscopic studies on the role of the envelope antigens of R-MuLV-ts29 in budding.
Virology. 1981 Aug;113(1):254-62 PMID: 6168098
Proteolytic enhancement of rotavirus infectivity: molecular mechanisms.
J Virol. 1981 Sep;39(3):879-88 PMID: 6270356
Comparisons of rotavirus polypeptides by limited proteolysis: close similarity of certain polypeptides of different strains.
J Virol. 1981 Dec;40(3):720-8 PMID: 6275113
Identification of rotavirus particle types.
Intervirology. 1981;16(1):20-8 PMID: 6276323
Preparation and characterization of antisera to electrophoretically purified SA11 virus polypeptides.
Infect Immun. 1981 Dec;34(3):641-7 PMID: 6174448
Effect of tunicamycin on the replication of Sendai virus.
Virology. 1982 Jun;119(2):474-87 PMID: 6281985
Gene protein products of SA11 simian rotavirus genome.
J Virol. 1982 Jan;41(1):42-50 PMID: 6283128
Herpesvirus glycoprotein synthesis and insertion into plasma membranes.
J Virol. 1982 May;42(2):678-90 PMID: 6283177
Identification, synthesis, and modifications of simian rotavirus SA11 polypeptides in infected cells.
J Virol. 1982 Jun;42(3):825-39 PMID: 6284998
Heterogeneity in the structural glycoprotein (VP7) of simian rotavirus SA11.
Virology. 1982 Oct 15;122(1):8-14 PMID: 6291238
Identification of a neutralization-specific antigen of a calf rotavirus.
J Gen Virol. 1982 Oct;62 (Pt 2):297-311 PMID: 6292353
Effect of tunicamycin on rotavirus assembly and infectivity.
J Virol. 1982 Sep;43(3):1082-90 PMID: 6292451
Association of viral particles and viral proteins with membranes in SA11-infected cells.
J Virol. 1982 Dec;44(3):983-92 PMID: 6294346
Localization of rotavirus antigens in infected cells by ultrastructural immunocytochemistry.
J Gen Virol. 1982 Dec;63(2):457-67 PMID: 6296288

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.46.1.270-274.1983

Published

1983-04-00

Pages

270-4

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC255116

Subset

Grants

NIADDK NIH HHS · AM 30144 · United States

NCI NIH HHS · CA 09197 · United States

NCRR NIH HHS · RR-05425 · United States

External Links

PubMed source DOI: 10.1128/JVI.46.1.270-274.1983 PMC Full Text View journal details

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Effects of tunicamycin on rotavirus morphogenesis and infectivity.

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